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Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing
Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia. BCL11A has been identified as a key regulator of HbF silencing, although its precise mechanisms of action remain incompletely understood. Recent studies have identified pathogenic mut...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530301/ https://www.ncbi.nlm.nih.gov/pubmed/34634037 http://dx.doi.org/10.1371/journal.pgen.1009835 |