Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells

RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prioritised as an attractive therapeutic target for the...

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Detalles Bibliográficos
Autores principales: Wilson, Paul A., Santos Franco, Sara, He, Liu, Galwey, Nicholas W., Meakin, Jackie, McIntyre, Rebecca, McHugh, Simon M., Nolan, Michael A., Spain, Sarah L., Carlson, Thaddeus, Lobera, Mercedes, Rubio, Justin P., Davis, Bill, McCarthy, Linda C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530322/
https://www.ncbi.nlm.nih.gov/pubmed/34673799
http://dx.doi.org/10.1371/journal.pone.0258316

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