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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay
Chagas disease, caused by the protozoan intracellular parasite Trypanosoma cruzi, is a highly neglected tropical disease, causing significant morbidity and mortality in central and south America. Current treatments are inadequate, and recent clinical trials of drugs inhibiting CYP51 have failed, exp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530327/ https://www.ncbi.nlm.nih.gov/pubmed/34634052 http://dx.doi.org/10.1371/journal.pntd.0009870 |