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Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis
The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and ox...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530328/ https://www.ncbi.nlm.nih.gov/pubmed/34673824 http://dx.doi.org/10.1371/journal.pone.0259064 |
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author | Ueda, Yuichiro Ookawara, Susumu Ito, Kiyonori Sasabuchi, Yusuke Hayasaka, Hideyuki Kofuji, Masaya Uchida, Takayuki Imai, Sojiro Kiryu, Satoshi Minato, Saori Miyazawa, Haruhisa Sanayama, Hidenori Hirai, Keiji Tabei, Kaoru Morishita, Yoshiyuki |
author_facet | Ueda, Yuichiro Ookawara, Susumu Ito, Kiyonori Sasabuchi, Yusuke Hayasaka, Hideyuki Kofuji, Masaya Uchida, Takayuki Imai, Sojiro Kiryu, Satoshi Minato, Saori Miyazawa, Haruhisa Sanayama, Hidenori Hirai, Keiji Tabei, Kaoru Morishita, Yoshiyuki |
author_sort | Ueda, Yuichiro |
collection | PubMed |
description | The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and oxygenation cannot be easily evaluated in the clinical setting of HD therapy. We included 185 HD patients and 15 healthy volunteers as the control group in this study. Before HD, hepatic regional oxygen saturation (rSO(2)), a marker of hepatic oxygenation reflecting the hepato-splanchnic circulation and oxygenation, was monitored using an INVOS 5100c oxygen saturation monitor. Hepatic rSO(2) was significantly lower in patients undergoing HD than in healthy controls (56.4 ± 14.9% vs. 76.2 ± 9.6%, p < 0.001). Multivariable regression analysis showed that hepatic rSO(2) was independently associated with body mass index (BMI; standardized coefficient: 0.294), hemoglobin (Hb) level (standardized coefficient: 0.294), a history of cardiovascular disease (standardized coefficient: -0.157), mean blood pressure (BP; standardized coefficient: 0.154), and serum albumin concentration (standardized coefficient: 0.150) in Model 1 via a simple linear regression analysis. In Model 2 using the colloid osmotic pressure (COP) in place of serum albumin concentration, the COP (standardized coefficient: 0.134) was also identified as affecting hepatic rSO(2). Basal hepatic oxygenation before HD might be affected by BMI, Hb levels, a history of cardiovascular disease, mean BP, serum albumin concentration, and the COP. Further prospective studies are needed to clarify whether changes in these parameters, including during HD, affect the hepato-splanchnic circulation and oxygenation in HD patients. |
format | Online Article Text |
id | pubmed-8530328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85303282021-10-22 Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis Ueda, Yuichiro Ookawara, Susumu Ito, Kiyonori Sasabuchi, Yusuke Hayasaka, Hideyuki Kofuji, Masaya Uchida, Takayuki Imai, Sojiro Kiryu, Satoshi Minato, Saori Miyazawa, Haruhisa Sanayama, Hidenori Hirai, Keiji Tabei, Kaoru Morishita, Yoshiyuki PLoS One Research Article The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and oxygenation cannot be easily evaluated in the clinical setting of HD therapy. We included 185 HD patients and 15 healthy volunteers as the control group in this study. Before HD, hepatic regional oxygen saturation (rSO(2)), a marker of hepatic oxygenation reflecting the hepato-splanchnic circulation and oxygenation, was monitored using an INVOS 5100c oxygen saturation monitor. Hepatic rSO(2) was significantly lower in patients undergoing HD than in healthy controls (56.4 ± 14.9% vs. 76.2 ± 9.6%, p < 0.001). Multivariable regression analysis showed that hepatic rSO(2) was independently associated with body mass index (BMI; standardized coefficient: 0.294), hemoglobin (Hb) level (standardized coefficient: 0.294), a history of cardiovascular disease (standardized coefficient: -0.157), mean blood pressure (BP; standardized coefficient: 0.154), and serum albumin concentration (standardized coefficient: 0.150) in Model 1 via a simple linear regression analysis. In Model 2 using the colloid osmotic pressure (COP) in place of serum albumin concentration, the COP (standardized coefficient: 0.134) was also identified as affecting hepatic rSO(2). Basal hepatic oxygenation before HD might be affected by BMI, Hb levels, a history of cardiovascular disease, mean BP, serum albumin concentration, and the COP. Further prospective studies are needed to clarify whether changes in these parameters, including during HD, affect the hepato-splanchnic circulation and oxygenation in HD patients. Public Library of Science 2021-10-21 /pmc/articles/PMC8530328/ /pubmed/34673824 http://dx.doi.org/10.1371/journal.pone.0259064 Text en © 2021 Ueda et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ueda, Yuichiro Ookawara, Susumu Ito, Kiyonori Sasabuchi, Yusuke Hayasaka, Hideyuki Kofuji, Masaya Uchida, Takayuki Imai, Sojiro Kiryu, Satoshi Minato, Saori Miyazawa, Haruhisa Sanayama, Hidenori Hirai, Keiji Tabei, Kaoru Morishita, Yoshiyuki Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
title | Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
title_full | Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
title_fullStr | Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
title_full_unstemmed | Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
title_short | Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
title_sort | association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530328/ https://www.ncbi.nlm.nih.gov/pubmed/34673824 http://dx.doi.org/10.1371/journal.pone.0259064 |
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