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Proof of concept for multiple nerve transfers to a single target muscle
Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the nu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530510/ https://www.ncbi.nlm.nih.gov/pubmed/34596042 http://dx.doi.org/10.7554/eLife.71312 |
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author | Luft, Matthias Klepetko, Johanna Muceli, Silvia Ibáñez, Jaime Tereshenko, Vlad Festin, Christopher Laengle, Gregor Politikou, Olga Maierhofer, Udo Farina, Dario Aszmann, Oskar C Bergmeister, Konstantin Davide |
author_facet | Luft, Matthias Klepetko, Johanna Muceli, Silvia Ibáñez, Jaime Tereshenko, Vlad Festin, Christopher Laengle, Gregor Politikou, Olga Maierhofer, Udo Farina, Dario Aszmann, Oskar C Bergmeister, Konstantin Davide |
author_sort | Luft, Matthias |
collection | PubMed |
description | Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the number of muscle signals for myoelectric prosthetic control and facilitate the treatment of multiple neuromas. Currently, no experimental models are available. This study describes a novel experimental model to investigate the neurophysiological effects of peripheral double nerve transfers to a common target muscle. In 62 male Sprague-Dawley rats, the ulnar nerve of the antebrachium alone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervate the long head of the biceps brachii. Before neurotization, the motor branch to the biceps’ long head was transected at the motor entry point. Twelve weeks after surgery, muscle response to neurotomy, behavioral testing, retrograde labeling, and structural analyses were performed to assess reinnervation. These analyses indicated that all nerves successfully reinnervated the target muscle. No aberrant reinnervation was observed by the originally innervating nerve. Our observations suggest a minimal burden for the animal with no signs of functional deficit in daily activities or auto-mutilation in both procedures. Furthermore, standard neurophysiological analyses for nerve and muscle regeneration were applicable. This newly developed nerve transfer model allows for the reliable and standardized investigation of neural and functional changes following the transfer of multiple donor nerves to one target muscle. |
format | Online Article Text |
id | pubmed-8530510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-85305102021-10-25 Proof of concept for multiple nerve transfers to a single target muscle Luft, Matthias Klepetko, Johanna Muceli, Silvia Ibáñez, Jaime Tereshenko, Vlad Festin, Christopher Laengle, Gregor Politikou, Olga Maierhofer, Udo Farina, Dario Aszmann, Oskar C Bergmeister, Konstantin Davide eLife Neuroscience Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the number of muscle signals for myoelectric prosthetic control and facilitate the treatment of multiple neuromas. Currently, no experimental models are available. This study describes a novel experimental model to investigate the neurophysiological effects of peripheral double nerve transfers to a common target muscle. In 62 male Sprague-Dawley rats, the ulnar nerve of the antebrachium alone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervate the long head of the biceps brachii. Before neurotization, the motor branch to the biceps’ long head was transected at the motor entry point. Twelve weeks after surgery, muscle response to neurotomy, behavioral testing, retrograde labeling, and structural analyses were performed to assess reinnervation. These analyses indicated that all nerves successfully reinnervated the target muscle. No aberrant reinnervation was observed by the originally innervating nerve. Our observations suggest a minimal burden for the animal with no signs of functional deficit in daily activities or auto-mutilation in both procedures. Furthermore, standard neurophysiological analyses for nerve and muscle regeneration were applicable. This newly developed nerve transfer model allows for the reliable and standardized investigation of neural and functional changes following the transfer of multiple donor nerves to one target muscle. eLife Sciences Publications, Ltd 2021-10-01 /pmc/articles/PMC8530510/ /pubmed/34596042 http://dx.doi.org/10.7554/eLife.71312 Text en © 2021, Luft et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Luft, Matthias Klepetko, Johanna Muceli, Silvia Ibáñez, Jaime Tereshenko, Vlad Festin, Christopher Laengle, Gregor Politikou, Olga Maierhofer, Udo Farina, Dario Aszmann, Oskar C Bergmeister, Konstantin Davide Proof of concept for multiple nerve transfers to a single target muscle |
title | Proof of concept for multiple nerve transfers to a single target muscle |
title_full | Proof of concept for multiple nerve transfers to a single target muscle |
title_fullStr | Proof of concept for multiple nerve transfers to a single target muscle |
title_full_unstemmed | Proof of concept for multiple nerve transfers to a single target muscle |
title_short | Proof of concept for multiple nerve transfers to a single target muscle |
title_sort | proof of concept for multiple nerve transfers to a single target muscle |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530510/ https://www.ncbi.nlm.nih.gov/pubmed/34596042 http://dx.doi.org/10.7554/eLife.71312 |
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