Cargando…

Proof of concept for multiple nerve transfers to a single target muscle

Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Luft, Matthias, Klepetko, Johanna, Muceli, Silvia, Ibáñez, Jaime, Tereshenko, Vlad, Festin, Christopher, Laengle, Gregor, Politikou, Olga, Maierhofer, Udo, Farina, Dario, Aszmann, Oskar C, Bergmeister, Konstantin Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530510/
https://www.ncbi.nlm.nih.gov/pubmed/34596042
http://dx.doi.org/10.7554/eLife.71312
_version_ 1784586678097149952
author Luft, Matthias
Klepetko, Johanna
Muceli, Silvia
Ibáñez, Jaime
Tereshenko, Vlad
Festin, Christopher
Laengle, Gregor
Politikou, Olga
Maierhofer, Udo
Farina, Dario
Aszmann, Oskar C
Bergmeister, Konstantin Davide
author_facet Luft, Matthias
Klepetko, Johanna
Muceli, Silvia
Ibáñez, Jaime
Tereshenko, Vlad
Festin, Christopher
Laengle, Gregor
Politikou, Olga
Maierhofer, Udo
Farina, Dario
Aszmann, Oskar C
Bergmeister, Konstantin Davide
author_sort Luft, Matthias
collection PubMed
description Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the number of muscle signals for myoelectric prosthetic control and facilitate the treatment of multiple neuromas. Currently, no experimental models are available. This study describes a novel experimental model to investigate the neurophysiological effects of peripheral double nerve transfers to a common target muscle. In 62 male Sprague-Dawley rats, the ulnar nerve of the antebrachium alone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervate the long head of the biceps brachii. Before neurotization, the motor branch to the biceps’ long head was transected at the motor entry point. Twelve weeks after surgery, muscle response to neurotomy, behavioral testing, retrograde labeling, and structural analyses were performed to assess reinnervation. These analyses indicated that all nerves successfully reinnervated the target muscle. No aberrant reinnervation was observed by the originally innervating nerve. Our observations suggest a minimal burden for the animal with no signs of functional deficit in daily activities or auto-mutilation in both procedures. Furthermore, standard neurophysiological analyses for nerve and muscle regeneration were applicable. This newly developed nerve transfer model allows for the reliable and standardized investigation of neural and functional changes following the transfer of multiple donor nerves to one target muscle.
format Online
Article
Text
id pubmed-8530510
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-85305102021-10-25 Proof of concept for multiple nerve transfers to a single target muscle Luft, Matthias Klepetko, Johanna Muceli, Silvia Ibáñez, Jaime Tereshenko, Vlad Festin, Christopher Laengle, Gregor Politikou, Olga Maierhofer, Udo Farina, Dario Aszmann, Oskar C Bergmeister, Konstantin Davide eLife Neuroscience Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the number of muscle signals for myoelectric prosthetic control and facilitate the treatment of multiple neuromas. Currently, no experimental models are available. This study describes a novel experimental model to investigate the neurophysiological effects of peripheral double nerve transfers to a common target muscle. In 62 male Sprague-Dawley rats, the ulnar nerve of the antebrachium alone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervate the long head of the biceps brachii. Before neurotization, the motor branch to the biceps’ long head was transected at the motor entry point. Twelve weeks after surgery, muscle response to neurotomy, behavioral testing, retrograde labeling, and structural analyses were performed to assess reinnervation. These analyses indicated that all nerves successfully reinnervated the target muscle. No aberrant reinnervation was observed by the originally innervating nerve. Our observations suggest a minimal burden for the animal with no signs of functional deficit in daily activities or auto-mutilation in both procedures. Furthermore, standard neurophysiological analyses for nerve and muscle regeneration were applicable. This newly developed nerve transfer model allows for the reliable and standardized investigation of neural and functional changes following the transfer of multiple donor nerves to one target muscle. eLife Sciences Publications, Ltd 2021-10-01 /pmc/articles/PMC8530510/ /pubmed/34596042 http://dx.doi.org/10.7554/eLife.71312 Text en © 2021, Luft et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Luft, Matthias
Klepetko, Johanna
Muceli, Silvia
Ibáñez, Jaime
Tereshenko, Vlad
Festin, Christopher
Laengle, Gregor
Politikou, Olga
Maierhofer, Udo
Farina, Dario
Aszmann, Oskar C
Bergmeister, Konstantin Davide
Proof of concept for multiple nerve transfers to a single target muscle
title Proof of concept for multiple nerve transfers to a single target muscle
title_full Proof of concept for multiple nerve transfers to a single target muscle
title_fullStr Proof of concept for multiple nerve transfers to a single target muscle
title_full_unstemmed Proof of concept for multiple nerve transfers to a single target muscle
title_short Proof of concept for multiple nerve transfers to a single target muscle
title_sort proof of concept for multiple nerve transfers to a single target muscle
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530510/
https://www.ncbi.nlm.nih.gov/pubmed/34596042
http://dx.doi.org/10.7554/eLife.71312
work_keys_str_mv AT luftmatthias proofofconceptformultiplenervetransferstoasingletargetmuscle
AT klepetkojohanna proofofconceptformultiplenervetransferstoasingletargetmuscle
AT mucelisilvia proofofconceptformultiplenervetransferstoasingletargetmuscle
AT ibanezjaime proofofconceptformultiplenervetransferstoasingletargetmuscle
AT tereshenkovlad proofofconceptformultiplenervetransferstoasingletargetmuscle
AT festinchristopher proofofconceptformultiplenervetransferstoasingletargetmuscle
AT laenglegregor proofofconceptformultiplenervetransferstoasingletargetmuscle
AT politikouolga proofofconceptformultiplenervetransferstoasingletargetmuscle
AT maierhoferudo proofofconceptformultiplenervetransferstoasingletargetmuscle
AT farinadario proofofconceptformultiplenervetransferstoasingletargetmuscle
AT aszmannoskarc proofofconceptformultiplenervetransferstoasingletargetmuscle
AT bergmeisterkonstantindavide proofofconceptformultiplenervetransferstoasingletargetmuscle