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Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia

CONTEXT: Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE: To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and ev...

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Autores principales: Nowotny, Hanna Franziska, Auer, Matthias K, Lottspeich, Christian, Schmidt, Heinrich, Dubinski, Ilja, Bidlingmaier, Martin, Adaway, Jo, Hawley, James, Keevil, Brian, Reisch, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530726/
https://www.ncbi.nlm.nih.gov/pubmed/34165575
http://dx.doi.org/10.1210/clinem/dgab446
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author Nowotny, Hanna Franziska
Auer, Matthias K
Lottspeich, Christian
Schmidt, Heinrich
Dubinski, Ilja
Bidlingmaier, Martin
Adaway, Jo
Hawley, James
Keevil, Brian
Reisch, Nicole
author_facet Nowotny, Hanna Franziska
Auer, Matthias K
Lottspeich, Christian
Schmidt, Heinrich
Dubinski, Ilja
Bidlingmaier, Martin
Adaway, Jo
Hawley, James
Keevil, Brian
Reisch, Nicole
author_sort Nowotny, Hanna Franziska
collection PubMed
description CONTEXT: Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE: To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and evaluate their relevance as potential monitoring parameters in 21OHD. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional single-center study including 59 patients with classic 21OHD (men = 30; women = 29) and 49 body mass index- and age-matched controls (men = 19; women = 30). OUTCOME MEASURES: Salivary concentrations of the following steroids were analyzed by liquid chromatography-tandem mass spectrometry: 17-hydroxyprogesterone (17OHP), androstenedione (A4), testosterone (T), 11β-hydroxyandrostenedione (11OHA4), and 11-ketotestosterone (11KT). RESULTS: Similar to the previously described rhythmicity of 17OHP, 11OHA4 and 11KT concentrations followed a distinct diurnal rhythm in both patients and controls with highest concentrations in the early morning and declining throughout the day (11-OHA4: mean reduction of hormone concentrations between timepoint 1 and 5 (Δ (mean)) in male patients = 66%; male controls Δ (mean) = 83%; female patients Δ (mean) = 47%; female controls Δ (mean) = 86%; 11KT: male patients Δ (mean) = 57%; male controls Δ (mean) = 63%; female patients Δ (mean) = 50%; female controls Δ (mean) = 76%). Significant correlations between the area under the curve for 17OHP and 11KT (r(p)(male) = 0.773(<0.0001); r(p)(female) = 0.737(<0.0001)), and 11OHA4 (r(p)(male) = 0.633(0.0002); r(p)(female) = 0.564(0.0014)) were observed in patients but not present or reduced in controls. CONCLUSIONS: Adrenal 11oxC19 androgens are secreted following a diurnal pattern. This should be considered when evaluating their utility for monitoring treatment control.
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spelling pubmed-85307262021-10-25 Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia Nowotny, Hanna Franziska Auer, Matthias K Lottspeich, Christian Schmidt, Heinrich Dubinski, Ilja Bidlingmaier, Martin Adaway, Jo Hawley, James Keevil, Brian Reisch, Nicole J Clin Endocrinol Metab Online Only Articles CONTEXT: Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE: To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and evaluate their relevance as potential monitoring parameters in 21OHD. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional single-center study including 59 patients with classic 21OHD (men = 30; women = 29) and 49 body mass index- and age-matched controls (men = 19; women = 30). OUTCOME MEASURES: Salivary concentrations of the following steroids were analyzed by liquid chromatography-tandem mass spectrometry: 17-hydroxyprogesterone (17OHP), androstenedione (A4), testosterone (T), 11β-hydroxyandrostenedione (11OHA4), and 11-ketotestosterone (11KT). RESULTS: Similar to the previously described rhythmicity of 17OHP, 11OHA4 and 11KT concentrations followed a distinct diurnal rhythm in both patients and controls with highest concentrations in the early morning and declining throughout the day (11-OHA4: mean reduction of hormone concentrations between timepoint 1 and 5 (Δ (mean)) in male patients = 66%; male controls Δ (mean) = 83%; female patients Δ (mean) = 47%; female controls Δ (mean) = 86%; 11KT: male patients Δ (mean) = 57%; male controls Δ (mean) = 63%; female patients Δ (mean) = 50%; female controls Δ (mean) = 76%). Significant correlations between the area under the curve for 17OHP and 11KT (r(p)(male) = 0.773(<0.0001); r(p)(female) = 0.737(<0.0001)), and 11OHA4 (r(p)(male) = 0.633(0.0002); r(p)(female) = 0.564(0.0014)) were observed in patients but not present or reduced in controls. CONCLUSIONS: Adrenal 11oxC19 androgens are secreted following a diurnal pattern. This should be considered when evaluating their utility for monitoring treatment control. Oxford University Press 2021-06-24 /pmc/articles/PMC8530726/ /pubmed/34165575 http://dx.doi.org/10.1210/clinem/dgab446 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Online Only Articles
Nowotny, Hanna Franziska
Auer, Matthias K
Lottspeich, Christian
Schmidt, Heinrich
Dubinski, Ilja
Bidlingmaier, Martin
Adaway, Jo
Hawley, James
Keevil, Brian
Reisch, Nicole
Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
title Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
title_full Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
title_fullStr Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
title_full_unstemmed Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
title_short Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
title_sort salivary profiles of 11-oxygenated androgens follow a diurnal rhythm in patients with congenital adrenal hyperplasia
topic Online Only Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530726/
https://www.ncbi.nlm.nih.gov/pubmed/34165575
http://dx.doi.org/10.1210/clinem/dgab446
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