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Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
CONTEXT: Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE: To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and ev...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530726/ https://www.ncbi.nlm.nih.gov/pubmed/34165575 http://dx.doi.org/10.1210/clinem/dgab446 |
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author | Nowotny, Hanna Franziska Auer, Matthias K Lottspeich, Christian Schmidt, Heinrich Dubinski, Ilja Bidlingmaier, Martin Adaway, Jo Hawley, James Keevil, Brian Reisch, Nicole |
author_facet | Nowotny, Hanna Franziska Auer, Matthias K Lottspeich, Christian Schmidt, Heinrich Dubinski, Ilja Bidlingmaier, Martin Adaway, Jo Hawley, James Keevil, Brian Reisch, Nicole |
author_sort | Nowotny, Hanna Franziska |
collection | PubMed |
description | CONTEXT: Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE: To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and evaluate their relevance as potential monitoring parameters in 21OHD. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional single-center study including 59 patients with classic 21OHD (men = 30; women = 29) and 49 body mass index- and age-matched controls (men = 19; women = 30). OUTCOME MEASURES: Salivary concentrations of the following steroids were analyzed by liquid chromatography-tandem mass spectrometry: 17-hydroxyprogesterone (17OHP), androstenedione (A4), testosterone (T), 11β-hydroxyandrostenedione (11OHA4), and 11-ketotestosterone (11KT). RESULTS: Similar to the previously described rhythmicity of 17OHP, 11OHA4 and 11KT concentrations followed a distinct diurnal rhythm in both patients and controls with highest concentrations in the early morning and declining throughout the day (11-OHA4: mean reduction of hormone concentrations between timepoint 1 and 5 (Δ (mean)) in male patients = 66%; male controls Δ (mean) = 83%; female patients Δ (mean) = 47%; female controls Δ (mean) = 86%; 11KT: male patients Δ (mean) = 57%; male controls Δ (mean) = 63%; female patients Δ (mean) = 50%; female controls Δ (mean) = 76%). Significant correlations between the area under the curve for 17OHP and 11KT (r(p)(male) = 0.773(<0.0001); r(p)(female) = 0.737(<0.0001)), and 11OHA4 (r(p)(male) = 0.633(0.0002); r(p)(female) = 0.564(0.0014)) were observed in patients but not present or reduced in controls. CONCLUSIONS: Adrenal 11oxC19 androgens are secreted following a diurnal pattern. This should be considered when evaluating their utility for monitoring treatment control. |
format | Online Article Text |
id | pubmed-8530726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-85307262021-10-25 Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia Nowotny, Hanna Franziska Auer, Matthias K Lottspeich, Christian Schmidt, Heinrich Dubinski, Ilja Bidlingmaier, Martin Adaway, Jo Hawley, James Keevil, Brian Reisch, Nicole J Clin Endocrinol Metab Online Only Articles CONTEXT: Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE: To analyze circadian rhythmicity of 11oxC19 steroids in saliva profiles and evaluate their relevance as potential monitoring parameters in 21OHD. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional single-center study including 59 patients with classic 21OHD (men = 30; women = 29) and 49 body mass index- and age-matched controls (men = 19; women = 30). OUTCOME MEASURES: Salivary concentrations of the following steroids were analyzed by liquid chromatography-tandem mass spectrometry: 17-hydroxyprogesterone (17OHP), androstenedione (A4), testosterone (T), 11β-hydroxyandrostenedione (11OHA4), and 11-ketotestosterone (11KT). RESULTS: Similar to the previously described rhythmicity of 17OHP, 11OHA4 and 11KT concentrations followed a distinct diurnal rhythm in both patients and controls with highest concentrations in the early morning and declining throughout the day (11-OHA4: mean reduction of hormone concentrations between timepoint 1 and 5 (Δ (mean)) in male patients = 66%; male controls Δ (mean) = 83%; female patients Δ (mean) = 47%; female controls Δ (mean) = 86%; 11KT: male patients Δ (mean) = 57%; male controls Δ (mean) = 63%; female patients Δ (mean) = 50%; female controls Δ (mean) = 76%). Significant correlations between the area under the curve for 17OHP and 11KT (r(p)(male) = 0.773(<0.0001); r(p)(female) = 0.737(<0.0001)), and 11OHA4 (r(p)(male) = 0.633(0.0002); r(p)(female) = 0.564(0.0014)) were observed in patients but not present or reduced in controls. CONCLUSIONS: Adrenal 11oxC19 androgens are secreted following a diurnal pattern. This should be considered when evaluating their utility for monitoring treatment control. Oxford University Press 2021-06-24 /pmc/articles/PMC8530726/ /pubmed/34165575 http://dx.doi.org/10.1210/clinem/dgab446 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Online Only Articles Nowotny, Hanna Franziska Auer, Matthias K Lottspeich, Christian Schmidt, Heinrich Dubinski, Ilja Bidlingmaier, Martin Adaway, Jo Hawley, James Keevil, Brian Reisch, Nicole Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia |
title | Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia |
title_full | Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia |
title_fullStr | Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia |
title_full_unstemmed | Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia |
title_short | Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia |
title_sort | salivary profiles of 11-oxygenated androgens follow a diurnal rhythm in patients with congenital adrenal hyperplasia |
topic | Online Only Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530726/ https://www.ncbi.nlm.nih.gov/pubmed/34165575 http://dx.doi.org/10.1210/clinem/dgab446 |
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