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Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma
PURPOSE: To describe the timing of chemotherapy initiation after surgery for Wilms tumor (WT) and neuroblastoma within a dedicated children’s cancer center. METHODS: A single-institution retrospective cohort study identified patients that underwent resection of unilateral WT or high-risk neuroblasto...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530895/ https://www.ncbi.nlm.nih.gov/pubmed/34268609 http://dx.doi.org/10.1007/s00383-021-04968-1 |
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author | Ross, A Gomez, O Wang, X Lu, Z Abdelhafeez, H Davidoff, AM Talbot, L Murphy, AJ |
author_facet | Ross, A Gomez, O Wang, X Lu, Z Abdelhafeez, H Davidoff, AM Talbot, L Murphy, AJ |
author_sort | Ross, A |
collection | PubMed |
description | PURPOSE: To describe the timing of chemotherapy initiation after surgery for Wilms tumor (WT) and neuroblastoma within a dedicated children’s cancer center. METHODS: A single-institution retrospective cohort study identified patients that underwent resection of unilateral WT or high-risk neuroblastoma and received adjuvant chemotherapy treatment. Adjuvant chemotherapy initiation and postoperative complications were recorded. RESULTS: Among 47 WT patients, the median time to chemotherapy initiation was 11 days [interquartile range IQR 7-14]. 3 WT patients had post-operative complications, but all preceded chemotherapy. Among 83 patients treated for high-risk neuroblastoma, the median time to chemotherapy was 11 days [IQR 9-14]. High-risk neuroblastoma patients with 30-day postoperative complications had a significantly longer time to initiation of adjuvant chemotherapy (odds ratio 1.13; p=0.008). Many of these complications preceded and delayed the initiation of post-operative chemotherapy. No complications occurred in the group of 12 (25%) WT patients or 16 (19.3%) neuroblastoma patients who started chemotherapy ≤7 days after surgery. CONCLUSION: There is no association between early initiation of adjuvant chemotherapy and post-operative complications including wound healing. Early initiation of chemotherapy (≤7 days) is feasible in unilateral WT or high-risk neuroblastoma patients who are otherwise doing well without resulting in a preponderance of wound healing complications. |
format | Online Article Text |
id | pubmed-8530895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-85308952022-11-01 Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma Ross, A Gomez, O Wang, X Lu, Z Abdelhafeez, H Davidoff, AM Talbot, L Murphy, AJ Pediatr Surg Int Article PURPOSE: To describe the timing of chemotherapy initiation after surgery for Wilms tumor (WT) and neuroblastoma within a dedicated children’s cancer center. METHODS: A single-institution retrospective cohort study identified patients that underwent resection of unilateral WT or high-risk neuroblastoma and received adjuvant chemotherapy treatment. Adjuvant chemotherapy initiation and postoperative complications were recorded. RESULTS: Among 47 WT patients, the median time to chemotherapy initiation was 11 days [interquartile range IQR 7-14]. 3 WT patients had post-operative complications, but all preceded chemotherapy. Among 83 patients treated for high-risk neuroblastoma, the median time to chemotherapy was 11 days [IQR 9-14]. High-risk neuroblastoma patients with 30-day postoperative complications had a significantly longer time to initiation of adjuvant chemotherapy (odds ratio 1.13; p=0.008). Many of these complications preceded and delayed the initiation of post-operative chemotherapy. No complications occurred in the group of 12 (25%) WT patients or 16 (19.3%) neuroblastoma patients who started chemotherapy ≤7 days after surgery. CONCLUSION: There is no association between early initiation of adjuvant chemotherapy and post-operative complications including wound healing. Early initiation of chemotherapy (≤7 days) is feasible in unilateral WT or high-risk neuroblastoma patients who are otherwise doing well without resulting in a preponderance of wound healing complications. 2021-07-15 2021-11 /pmc/articles/PMC8530895/ /pubmed/34268609 http://dx.doi.org/10.1007/s00383-021-04968-1 Text en https://creativecommons.org/licenses/by/4.0/Under no circumstances may this AM be shared or distributed under a Creative Commons or other form of open access license, nor may it be reformatted or enhanced, whether by the Author or third parties. See here for Springer Nature’s terms of use for AM versions of subscription articles: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms |
spellingShingle | Article Ross, A Gomez, O Wang, X Lu, Z Abdelhafeez, H Davidoff, AM Talbot, L Murphy, AJ Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma |
title | Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma |
title_full | Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma |
title_fullStr | Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma |
title_full_unstemmed | Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma |
title_short | Timing of Adjuvant Chemotherapy after Laparotomy for Wilms Tumor and Neuroblastoma |
title_sort | timing of adjuvant chemotherapy after laparotomy for wilms tumor and neuroblastoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530895/ https://www.ncbi.nlm.nih.gov/pubmed/34268609 http://dx.doi.org/10.1007/s00383-021-04968-1 |
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