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A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

PURPOSE: To evaluate the safety and tolerability in phase I first-in-human combination therapy with pexidartinib, an inhibitor of colony-stimulating factor-1 receptor, and sirolimus, an mTOR inhibitor, to target tumor-associated macrophage (TAM) polarization in soft tissue sarcomas (STS). PATIENTS A...

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Detalles Bibliográficos
Autores principales:	Manji, Gulam A., Van Tine, Brian A., Lee, Shing M., Raufi, Alexander G., Pellicciotta, Ilenia, Hirbe, Angela C., Pradhan, Jaya, Chen, Andrew, Rabadan, Raul, Schwartz, Gary K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Clinical Trials: Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530953/ https://www.ncbi.nlm.nih.gov/pubmed/34321280 http://dx.doi.org/10.1158/1078-0432.CCR-21-1779

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