Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Metastatic melanoma is challenging to clinically address. Although standard-of-care targeted therapy has high response rates in patients with BRAF-mutant melanoma, therapy relapse occurs in most cases. Intrinsically resistant melanoma cells drive therapy resistance and display molecular and biologic...

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Detalles Bibliográficos
Autores principales: Liu, Jianglan, Rebecca, Vito W., Kossenkov, Andrew V., Connelly, Thomas, Liu, Qin, Gutierrez, Alexis, Xiao, Min, Li, Ling, Zhang, Gao, Samarkina, Anastasia, Zayasbazan, Delaine, Zhang, Jie, Cheng, Chaoran, Wei, Zhi, Alicea, Gretchen M., Fukunaga-Kalabis, Mizuho, Krepler, Clemens, Aza-Blanc, Pedro, Yang, Chih-Cheng, Delvadia, Bela, Tong, Cynthia, Huang, Ye, Delvadia, Maya, Morias, Alice S., Sproesser, Katrin, Brafford, Patricia, Wang, Joshua X., Beqiri, Marilda, Somasundaram, Rajasekharan, Vultur, Adina, Hristova, Denitsa M., Wu, Lawrence W., Lu, Yiling, Mills, Gordon B., Xu, Wei, Karakousis, Giorgos C., Xu, Xiaowei, Schuchter, Lynn M., Mitchell, Tara C., Amaravadi, Ravi K., Kwong, Lawrence N., Frederick, Dennie T., Boland, Genevieve M., Salvino, Joseph M., Speicher, David W., Flaherty, Keith T., Ronai, Ze'ev A., Herlyn, Meenhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530965/
https://www.ncbi.nlm.nih.gov/pubmed/34462276
http://dx.doi.org/10.1158/0008-5472.CAN-20-1496

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