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Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

The N13 component of somatosensory evoked potential (N13 SEP) represents the segmental response of dorsal horn neurons. In this neurophysiological study, we aimed to verify whether N13 SEP might reflect excitability changes of dorsal horn neurons during central sensitization. In 22 healthy participa...

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Autores principales: Di Lionardo, A., Di Stefano, G., Leone, C., Di Pietro, G., Sgro, E., Malara, E., Cosentino, C., Mollica, C., Blockeel, A. J., Caspani, O., Garcia-Larrea, L., Mouraux, A., Treede, R. D., Phillips, K. G., Valeriani, M., Truini, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531029/
https://www.ncbi.nlm.nih.gov/pubmed/34675309
http://dx.doi.org/10.1038/s41598-021-00313-7
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author Di Lionardo, A.
Di Stefano, G.
Leone, C.
Di Pietro, G.
Sgro, E.
Malara, E.
Cosentino, C.
Mollica, C.
Blockeel, A. J.
Caspani, O.
Garcia-Larrea, L.
Mouraux, A.
Treede, R. D.
Phillips, K. G.
Valeriani, M.
Truini, Andrea
author_facet Di Lionardo, A.
Di Stefano, G.
Leone, C.
Di Pietro, G.
Sgro, E.
Malara, E.
Cosentino, C.
Mollica, C.
Blockeel, A. J.
Caspani, O.
Garcia-Larrea, L.
Mouraux, A.
Treede, R. D.
Phillips, K. G.
Valeriani, M.
Truini, Andrea
author_sort Di Lionardo, A.
collection PubMed
description The N13 component of somatosensory evoked potential (N13 SEP) represents the segmental response of dorsal horn neurons. In this neurophysiological study, we aimed to verify whether N13 SEP might reflect excitability changes of dorsal horn neurons during central sensitization. In 22 healthy participants, we investigated how central sensitization induced by application of topical capsaicin to the ulnar nerve territory of the hand dorsum modulated N13 SEP elicited by ulnar nerve stimulation. Using a double-blind placebo-controlled crossover design, we also tested whether pregabalin, an analgesic drug with proven efficacy on the dorsal horn, influenced capsaicin-induced N13 SEP modulation. Topical application of capsaicin produced an area of secondary mechanical hyperalgesia, a sign of central sensitization, and increased the N13 SEP amplitude but not the peripheral N9 nor the cortical N20-P25 amplitude. This increase in N13 SEP amplitude paralleled the mechanical hyperalgesia and persisted for 120 min. Pregabalin prevented the N13 SEP modulation associated with capsaicin-induced central sensitization, whereas capsaicin application still increased N13 SEP amplitude in the placebo treatment session. Our neurophysiological study showed that capsaicin application specifically modulates N13 SEP and that this modulation is prevented by pregabalin, thus suggesting that N13 SEP may reflect changes in dorsal horn excitability and represent a useful biomarker of central sensitization in human studies.
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spelling pubmed-85310292021-10-22 Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans Di Lionardo, A. Di Stefano, G. Leone, C. Di Pietro, G. Sgro, E. Malara, E. Cosentino, C. Mollica, C. Blockeel, A. J. Caspani, O. Garcia-Larrea, L. Mouraux, A. Treede, R. D. Phillips, K. G. Valeriani, M. Truini, Andrea Sci Rep Article The N13 component of somatosensory evoked potential (N13 SEP) represents the segmental response of dorsal horn neurons. In this neurophysiological study, we aimed to verify whether N13 SEP might reflect excitability changes of dorsal horn neurons during central sensitization. In 22 healthy participants, we investigated how central sensitization induced by application of topical capsaicin to the ulnar nerve territory of the hand dorsum modulated N13 SEP elicited by ulnar nerve stimulation. Using a double-blind placebo-controlled crossover design, we also tested whether pregabalin, an analgesic drug with proven efficacy on the dorsal horn, influenced capsaicin-induced N13 SEP modulation. Topical application of capsaicin produced an area of secondary mechanical hyperalgesia, a sign of central sensitization, and increased the N13 SEP amplitude but not the peripheral N9 nor the cortical N20-P25 amplitude. This increase in N13 SEP amplitude paralleled the mechanical hyperalgesia and persisted for 120 min. Pregabalin prevented the N13 SEP modulation associated with capsaicin-induced central sensitization, whereas capsaicin application still increased N13 SEP amplitude in the placebo treatment session. Our neurophysiological study showed that capsaicin application specifically modulates N13 SEP and that this modulation is prevented by pregabalin, thus suggesting that N13 SEP may reflect changes in dorsal horn excitability and represent a useful biomarker of central sensitization in human studies. Nature Publishing Group UK 2021-10-21 /pmc/articles/PMC8531029/ /pubmed/34675309 http://dx.doi.org/10.1038/s41598-021-00313-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Di Lionardo, A.
Di Stefano, G.
Leone, C.
Di Pietro, G.
Sgro, E.
Malara, E.
Cosentino, C.
Mollica, C.
Blockeel, A. J.
Caspani, O.
Garcia-Larrea, L.
Mouraux, A.
Treede, R. D.
Phillips, K. G.
Valeriani, M.
Truini, Andrea
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
title Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
title_full Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
title_fullStr Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
title_full_unstemmed Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
title_short Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
title_sort modulation of the n13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531029/
https://www.ncbi.nlm.nih.gov/pubmed/34675309
http://dx.doi.org/10.1038/s41598-021-00313-7
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