Genetic Advances in Autism

In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large...

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Detalles Bibliográficos
Autores principales: Thapar, Anita, Rutter, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
S:I Autism in Review: 1980-2020: 40 years after DSM-III
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531042/
https://www.ncbi.nlm.nih.gov/pubmed/32940822
http://dx.doi.org/10.1007/s10803-020-04685-z
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author Thapar, Anita
Rutter, Michael
author_facet Thapar, Anita
Rutter, Michael
author_sort Thapar, Anita
collection PubMed
description In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene variants all contribute to autism risk. These discoveries challenge traditional diagnostic boundaries and highlight huge heterogeneity in autism. In this review, we consider some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians.
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spelling pubmed-85310422021-11-04 Genetic Advances in Autism Thapar, Anita Rutter, Michael J Autism Dev Disord S:I Autism in Review: 1980-2020: 40 years after DSM-III In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene variants all contribute to autism risk. These discoveries challenge traditional diagnostic boundaries and highlight huge heterogeneity in autism. In this review, we consider some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians. Springer US 2020-09-17 2021 /pmc/articles/PMC8531042/ /pubmed/32940822 http://dx.doi.org/10.1007/s10803-020-04685-z Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle S:I Autism in Review: 1980-2020: 40 years after DSM-III
Thapar, Anita
Rutter, Michael
Genetic Advances in Autism
title Genetic Advances in Autism
title_full Genetic Advances in Autism
title_fullStr Genetic Advances in Autism
title_full_unstemmed Genetic Advances in Autism
title_short Genetic Advances in Autism
title_sort genetic advances in autism
topic S:I Autism in Review: 1980-2020: 40 years after DSM-III
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531042/
https://www.ncbi.nlm.nih.gov/pubmed/32940822
http://dx.doi.org/10.1007/s10803-020-04685-z
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