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Perspectives and limits of cancer treatment in an oldest old population

BACKGROUND: Population of oldest old will grow dramatically in the next future and cancer, physiologically related to aging, will be very prevalent among them. Lack of evidence is a huge problem to manage cancer in oldest old and will be more and more in the next years. AIMS: Our purpose was to inve...

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Autores principales: Di Capua, Beatrice, Bellieni, Andrea, Fusco, Domenico, Gambacorta, Maria Antonietta, Tagliaferri, Luca, Villani, Emanuele Rocco, Bernabei, Roberto, Valentini, Vincenzo, Colloca, Giuseppe Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531055/
https://www.ncbi.nlm.nih.gov/pubmed/33704699
http://dx.doi.org/10.1007/s40520-021-01821-2
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author Di Capua, Beatrice
Bellieni, Andrea
Fusco, Domenico
Gambacorta, Maria Antonietta
Tagliaferri, Luca
Villani, Emanuele Rocco
Bernabei, Roberto
Valentini, Vincenzo
Colloca, Giuseppe Ferdinando
author_facet Di Capua, Beatrice
Bellieni, Andrea
Fusco, Domenico
Gambacorta, Maria Antonietta
Tagliaferri, Luca
Villani, Emanuele Rocco
Bernabei, Roberto
Valentini, Vincenzo
Colloca, Giuseppe Ferdinando
author_sort Di Capua, Beatrice
collection PubMed
description BACKGROUND: Population of oldest old will grow dramatically in the next future and cancer, physiologically related to aging, will be very prevalent among them. Lack of evidence is a huge problem to manage cancer in oldest old and will be more and more in the next years. AIMS: Our purpose was to investigate the characteristics of a population of oldest old patients with cancer treated in the Radiation Oncology Unit of Fondazione Policlinico A. Gemelli IRCCS. METHODS: We conducted a retrospective study. The primary outcome was to evaluate which characteristics of the population could influence the choice of oncological treatment (with radical or non-radical intent). RESULTS: We identified a total of 348 patients: 140 were on follow-up; 177 were under treatment; 31 were considered not eligible for treatments. Patients under treatment had a high comorbidity index (mean Charlson Comorbidity Index 5.4), and a high prevalence of polypharmacy (mean number of drugs 5.6). More than half (53.1%) was treated with radical intent. Patients treated with radical intent were 1 year younger (87.1 years old vs 88.1 years old), more performant (ECOG 0.7 vs 1.3), and had less prevalence of metastatic neoplasia (6.4% vs 34.9%); comorbidities and drugs did not show differences in the two groups. CONCLUSION: Oldest old, usually not considered in international guidelines, are treated for oncological disease, often with radical intent. The treatment seems not to be tailored considering comorbidities but on performance status.
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spelling pubmed-85310552021-11-04 Perspectives and limits of cancer treatment in an oldest old population Di Capua, Beatrice Bellieni, Andrea Fusco, Domenico Gambacorta, Maria Antonietta Tagliaferri, Luca Villani, Emanuele Rocco Bernabei, Roberto Valentini, Vincenzo Colloca, Giuseppe Ferdinando Aging Clin Exp Res Original Article BACKGROUND: Population of oldest old will grow dramatically in the next future and cancer, physiologically related to aging, will be very prevalent among them. Lack of evidence is a huge problem to manage cancer in oldest old and will be more and more in the next years. AIMS: Our purpose was to investigate the characteristics of a population of oldest old patients with cancer treated in the Radiation Oncology Unit of Fondazione Policlinico A. Gemelli IRCCS. METHODS: We conducted a retrospective study. The primary outcome was to evaluate which characteristics of the population could influence the choice of oncological treatment (with radical or non-radical intent). RESULTS: We identified a total of 348 patients: 140 were on follow-up; 177 were under treatment; 31 were considered not eligible for treatments. Patients under treatment had a high comorbidity index (mean Charlson Comorbidity Index 5.4), and a high prevalence of polypharmacy (mean number of drugs 5.6). More than half (53.1%) was treated with radical intent. Patients treated with radical intent were 1 year younger (87.1 years old vs 88.1 years old), more performant (ECOG 0.7 vs 1.3), and had less prevalence of metastatic neoplasia (6.4% vs 34.9%); comorbidities and drugs did not show differences in the two groups. CONCLUSION: Oldest old, usually not considered in international guidelines, are treated for oncological disease, often with radical intent. The treatment seems not to be tailored considering comorbidities but on performance status. Springer International Publishing 2021-03-11 2021 /pmc/articles/PMC8531055/ /pubmed/33704699 http://dx.doi.org/10.1007/s40520-021-01821-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Di Capua, Beatrice
Bellieni, Andrea
Fusco, Domenico
Gambacorta, Maria Antonietta
Tagliaferri, Luca
Villani, Emanuele Rocco
Bernabei, Roberto
Valentini, Vincenzo
Colloca, Giuseppe Ferdinando
Perspectives and limits of cancer treatment in an oldest old population
title Perspectives and limits of cancer treatment in an oldest old population
title_full Perspectives and limits of cancer treatment in an oldest old population
title_fullStr Perspectives and limits of cancer treatment in an oldest old population
title_full_unstemmed Perspectives and limits of cancer treatment in an oldest old population
title_short Perspectives and limits of cancer treatment in an oldest old population
title_sort perspectives and limits of cancer treatment in an oldest old population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531055/
https://www.ncbi.nlm.nih.gov/pubmed/33704699
http://dx.doi.org/10.1007/s40520-021-01821-2
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