Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome

A common feature of diverse brain disorders is the alteration of GABA-mediated inhibition because of aberrant, intracellular chloride homeostasis induced by changes in the expression and/or function of chloride transporters. Notably, pharmacological inhibition of the chloride importer NKCC1 is able...

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Detalles Bibliográficos
Autores principales: Parrini, Martina, Naskar, Shovan, Alberti, Micol, Colombi, Ilaria, Morelli, Giovanni, Rocchi, Anna, Nanni, Marina, Piccardi, Federica, Charles, Severine, Ronzitti, Giuseppe, Mingozzi, Federico, Contestabile, Andrea, Cancedda, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531145/
https://www.ncbi.nlm.nih.gov/pubmed/34058387
http://dx.doi.org/10.1016/j.ymthe.2021.05.023

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