BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma

Glioblastoma (GBM) is the deadliest brain malignancy without effective treatments. Here, we reported that epidermal growth factor receptor-targeted chimeric antigen receptor T cells (EGFR CAR-T) were effective in suppressing the growth of GBM cells in vitro and xenografts derived from GBM cell lines...

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Detalles Bibliográficos
Autores principales: Xia, Lin, Liu, Jun-yi, Zheng, Zao-zao, Chen, Yu-jie, Ding, Jian-cheng, Hu, Ya-hong, Hu, Guo-sheng, Xia, Ning-shao, Liu, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531146/
https://www.ncbi.nlm.nih.gov/pubmed/34058385
http://dx.doi.org/10.1016/j.ymthe.2021.05.019

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