Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy

Early-onset epileptic encephalopathies are severe disorders often associated with specific genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterized by early-onset seizures, intellectual delay, and motor dysfunction. Although crucial for...

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Detalles Bibliográficos
Autores principales: Negraes, Priscilla D., Trujillo, Cleber A., Yu, Nam-Kyung, Wu, Wei, Yao, Hang, Liang, Nicholas, Lautz, Jonathan D., Kwok, Ellius, McClatchy, Daniel, Diedrich, Jolene, de Bartolome, Salvador Martinez, Truong, Justin, Szeto, Ryan, Tran, Timothy, Herai, Roberto H., Smith, Stephen E. P., Haddad, Gabriel G., Yates, John R., Muotri, Alysson R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531162/
https://www.ncbi.nlm.nih.gov/pubmed/33888873
http://dx.doi.org/10.1038/s41380-021-01104-2

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