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Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic

The outbreak of the coronavirus disease 2019 (COVID-19) has now spread throughout the globe infecting over 150 million people and causing the death of over 3.2 million people. Thus, there is an urgent need to study the dynamics of epidemiological models to gain a better understanding of how such dis...

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Autores principales: Quilodrán-Casas, César, Silva, Vinicius L.S., Arcucci, Rossella, Heaney, Claire E., Guo, YiKe, Pain, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531233/
https://www.ncbi.nlm.nih.gov/pubmed/34703079
http://dx.doi.org/10.1016/j.neucom.2021.10.043
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author Quilodrán-Casas, César
Silva, Vinicius L.S.
Arcucci, Rossella
Heaney, Claire E.
Guo, YiKe
Pain, Christopher C.
author_facet Quilodrán-Casas, César
Silva, Vinicius L.S.
Arcucci, Rossella
Heaney, Claire E.
Guo, YiKe
Pain, Christopher C.
author_sort Quilodrán-Casas, César
collection PubMed
description The outbreak of the coronavirus disease 2019 (COVID-19) has now spread throughout the globe infecting over 150 million people and causing the death of over 3.2 million people. Thus, there is an urgent need to study the dynamics of epidemiological models to gain a better understanding of how such diseases spread. While epidemiological models can be computationally expensive, recent advances in machine learning techniques have given rise to neural networks with the ability to learn and predict complex dynamics at reduced computational costs. Here we introduce two digital twins of a SEIRS model applied to an idealised town. The SEIRS model has been modified to take account of spatial variation and, where possible, the model parameters are based on official virus spreading data from the UK. We compare predictions from one digital twin based on a data-corrected Bidirectional Long Short-Term Memory network with predictions from another digital twin based on a predictive Generative Adversarial Network. The predictions given by these two frameworks are accurate when compared to the original SEIRS model data. Additionally, these frameworks are data-agnostic and could be applied to towns, idealised or real, in the UK or in other countries. Also, more compartments could be included in the SEIRS model, in order to study more realistic epidemiological behaviour.
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spelling pubmed-85312332021-10-22 Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic Quilodrán-Casas, César Silva, Vinicius L.S. Arcucci, Rossella Heaney, Claire E. Guo, YiKe Pain, Christopher C. Neurocomputing Article The outbreak of the coronavirus disease 2019 (COVID-19) has now spread throughout the globe infecting over 150 million people and causing the death of over 3.2 million people. Thus, there is an urgent need to study the dynamics of epidemiological models to gain a better understanding of how such diseases spread. While epidemiological models can be computationally expensive, recent advances in machine learning techniques have given rise to neural networks with the ability to learn and predict complex dynamics at reduced computational costs. Here we introduce two digital twins of a SEIRS model applied to an idealised town. The SEIRS model has been modified to take account of spatial variation and, where possible, the model parameters are based on official virus spreading data from the UK. We compare predictions from one digital twin based on a data-corrected Bidirectional Long Short-Term Memory network with predictions from another digital twin based on a predictive Generative Adversarial Network. The predictions given by these two frameworks are accurate when compared to the original SEIRS model data. Additionally, these frameworks are data-agnostic and could be applied to towns, idealised or real, in the UK or in other countries. Also, more compartments could be included in the SEIRS model, in order to study more realistic epidemiological behaviour. Elsevier B.V. 2022-01-22 2021-10-22 /pmc/articles/PMC8531233/ /pubmed/34703079 http://dx.doi.org/10.1016/j.neucom.2021.10.043 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Quilodrán-Casas, César
Silva, Vinicius L.S.
Arcucci, Rossella
Heaney, Claire E.
Guo, YiKe
Pain, Christopher C.
Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic
title Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic
title_full Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic
title_fullStr Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic
title_full_unstemmed Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic
title_short Digital twins based on bidirectional LSTM and GAN for modelling the COVID-19 pandemic
title_sort digital twins based on bidirectional lstm and gan for modelling the covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531233/
https://www.ncbi.nlm.nih.gov/pubmed/34703079
http://dx.doi.org/10.1016/j.neucom.2021.10.043
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