Cargando…

Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia

Background: Patients with comitant exotropia (CE) are accompanied by abnormal eye movements and stereovision. However, the neurophysiological mechanism of impaired eye movements and stereovision in patient with CE is still unclear. Purpose: The purpose of this study is to investigate spontaneous neu...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Juan, Jin, Han, Zhong, Yu-Lin, Huang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531266/
https://www.ncbi.nlm.nih.gov/pubmed/34690728
http://dx.doi.org/10.3389/fnhum.2021.754234
_version_ 1784586816365527040
author Chen, Juan
Jin, Han
Zhong, Yu-Lin
Huang, Xin
author_facet Chen, Juan
Jin, Han
Zhong, Yu-Lin
Huang, Xin
author_sort Chen, Juan
collection PubMed
description Background: Patients with comitant exotropia (CE) are accompanied by abnormal eye movements and stereovision. However, the neurophysiological mechanism of impaired eye movements and stereovision in patient with CE is still unclear. Purpose: The purpose of this study is to investigate spontaneous neural activity changes in patients with CE using the amplitude of low-frequency fluctuation (ALFF) method and the machine learning method. Materials and Methods: A total of 21 patients with CE and 21 healthy controls (HCs) underwent resting-state magnetic resonance imaging scans. The ALFF and fractional amplitude of low-frequency fluctuation (fALFF) values were chosen as classification features using a machine learning method. Results: Compared with the HC group, patients with CE had significantly decreased ALFF values in the right angular (ANG)/middle occipital gyrus (MOG)/middle temporal gyrus (MTG) and bilateral supplementary motor area (SMA)/precentral gyrus (PreCG). Meanwhile, patients with CE showed significantly increased fALFF values in the left putamen (PUT) and decreased fALFF values in the right ANG/MOG. Moreover, patients with CE showed a decreased functional connectivity (FC) between the right ANG/MOG/MTG and the bilateral calcarine (CAL)/lingual (LING) and increased FC between the left PUT and the bilateral cerebellum 8/9 (CER 8/9). The support vector machine (SVM) classification reaches a total accuracy of 93 and 90% and the area under the curve (AUC) of 0.93 and 0.90 based on ALFF and fALFF values, respectively. Conclusion: Our result highlights that patients with CE had abnormal brain neural activities including MOG and supplementary motor area/PreCG, which might reflect the neural mechanism of eye movements and stereovision dysfunction in patients with CE. Moreover, ALFF and fALFF could be sensitive biomarkers for distinguishing patients with CE from HCs.
format Online
Article
Text
id pubmed-8531266
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85312662021-10-23 Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia Chen, Juan Jin, Han Zhong, Yu-Lin Huang, Xin Front Hum Neurosci Human Neuroscience Background: Patients with comitant exotropia (CE) are accompanied by abnormal eye movements and stereovision. However, the neurophysiological mechanism of impaired eye movements and stereovision in patient with CE is still unclear. Purpose: The purpose of this study is to investigate spontaneous neural activity changes in patients with CE using the amplitude of low-frequency fluctuation (ALFF) method and the machine learning method. Materials and Methods: A total of 21 patients with CE and 21 healthy controls (HCs) underwent resting-state magnetic resonance imaging scans. The ALFF and fractional amplitude of low-frequency fluctuation (fALFF) values were chosen as classification features using a machine learning method. Results: Compared with the HC group, patients with CE had significantly decreased ALFF values in the right angular (ANG)/middle occipital gyrus (MOG)/middle temporal gyrus (MTG) and bilateral supplementary motor area (SMA)/precentral gyrus (PreCG). Meanwhile, patients with CE showed significantly increased fALFF values in the left putamen (PUT) and decreased fALFF values in the right ANG/MOG. Moreover, patients with CE showed a decreased functional connectivity (FC) between the right ANG/MOG/MTG and the bilateral calcarine (CAL)/lingual (LING) and increased FC between the left PUT and the bilateral cerebellum 8/9 (CER 8/9). The support vector machine (SVM) classification reaches a total accuracy of 93 and 90% and the area under the curve (AUC) of 0.93 and 0.90 based on ALFF and fALFF values, respectively. Conclusion: Our result highlights that patients with CE had abnormal brain neural activities including MOG and supplementary motor area/PreCG, which might reflect the neural mechanism of eye movements and stereovision dysfunction in patients with CE. Moreover, ALFF and fALFF could be sensitive biomarkers for distinguishing patients with CE from HCs. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531266/ /pubmed/34690728 http://dx.doi.org/10.3389/fnhum.2021.754234 Text en Copyright © 2021 Chen, Jin, Zhong and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Chen, Juan
Jin, Han
Zhong, Yu-Lin
Huang, Xin
Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia
title Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia
title_full Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia
title_fullStr Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia
title_full_unstemmed Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia
title_short Abnormal Low-Frequency Oscillations Reflect Abnormal Eye Movement and Stereovision in Patients With Comitant Exotropia
title_sort abnormal low-frequency oscillations reflect abnormal eye movement and stereovision in patients with comitant exotropia
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531266/
https://www.ncbi.nlm.nih.gov/pubmed/34690728
http://dx.doi.org/10.3389/fnhum.2021.754234
work_keys_str_mv AT chenjuan abnormallowfrequencyoscillationsreflectabnormaleyemovementandstereovisioninpatientswithcomitantexotropia
AT jinhan abnormallowfrequencyoscillationsreflectabnormaleyemovementandstereovisioninpatientswithcomitantexotropia
AT zhongyulin abnormallowfrequencyoscillationsreflectabnormaleyemovementandstereovisioninpatientswithcomitantexotropia
AT huangxin abnormallowfrequencyoscillationsreflectabnormaleyemovementandstereovisioninpatientswithcomitantexotropia