Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate the regulator flhDC to drive invasion...

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Detalles Bibliográficos
Autores principales: Raman, Vishnu, Van Dessel, Nele, Hall, Christopher L., Wetherby, Victoria E., Whitney, Samantha A., Kolewe, Emily L., Bloom, Shoshana M. K., Sharma, Abhinav, Hardy, Jeanne A., Bollen, Mathieu, Van Eynde, Aleyde, Forbes, Neil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531320/
https://www.ncbi.nlm.nih.gov/pubmed/34675204
http://dx.doi.org/10.1038/s41467-021-26367-9

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