Point mutations in Candida glabrata 3-hydroxy-3-methylglutaryl-coenzyme A reductase (CgHMGR) decrease enzymatic activity and substrate/inhibitor affinity

3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is a crucial enzyme in the ergosterol biosynthesis pathway. The aim of this study was to obtain, purify, characterize, and overexpress five point mutations in highly conserved regions of the catalytic domain of Candida glabrata HMGR (CgHMGR) to...

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Detalles Bibliográficos
Autores principales: Andrade-Pavón, Dulce, Fernández-Muñoz, Vanessa, González-Ibarra, Wendy, Hernández-Rodríguez, César, Ibarra, J. Antonio, Villa-Tanaca, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531335/
https://www.ncbi.nlm.nih.gov/pubmed/34675283
http://dx.doi.org/10.1038/s41598-021-00356-w

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