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The role of network connectivity on epileptiform activity

A number of potentially important mechanisms have been identified as key players to generate epileptiform activity, such as genetic mutations, activity-dependent alteration of synaptic functions, and functional network reorganization at the macroscopic level. Here we study how network connectivity a...

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Detalles Bibliográficos
Autores principales: Giacopelli, G., Tegolo, D., Migliore, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531347/
https://www.ncbi.nlm.nih.gov/pubmed/34675264
http://dx.doi.org/10.1038/s41598-021-00283-w
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author Giacopelli, G.
Tegolo, D.
Migliore, M.
author_facet Giacopelli, G.
Tegolo, D.
Migliore, M.
author_sort Giacopelli, G.
collection PubMed
description A number of potentially important mechanisms have been identified as key players to generate epileptiform activity, such as genetic mutations, activity-dependent alteration of synaptic functions, and functional network reorganization at the macroscopic level. Here we study how network connectivity at cellular level can affect the onset of epileptiform activity, using computational model networks with different wiring properties. The model suggests that networks connected as in real brain circuits are more resistant to generate seizure-like activity. The results suggest new experimentally testable predictions on the cellular network connectivity in epileptic individuals, and highlight the importance of using the appropriate network connectivity to investigate epileptiform activity with computational models.
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spelling pubmed-85313472021-10-22 The role of network connectivity on epileptiform activity Giacopelli, G. Tegolo, D. Migliore, M. Sci Rep Article A number of potentially important mechanisms have been identified as key players to generate epileptiform activity, such as genetic mutations, activity-dependent alteration of synaptic functions, and functional network reorganization at the macroscopic level. Here we study how network connectivity at cellular level can affect the onset of epileptiform activity, using computational model networks with different wiring properties. The model suggests that networks connected as in real brain circuits are more resistant to generate seizure-like activity. The results suggest new experimentally testable predictions on the cellular network connectivity in epileptic individuals, and highlight the importance of using the appropriate network connectivity to investigate epileptiform activity with computational models. Nature Publishing Group UK 2021-10-21 /pmc/articles/PMC8531347/ /pubmed/34675264 http://dx.doi.org/10.1038/s41598-021-00283-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Giacopelli, G.
Tegolo, D.
Migliore, M.
The role of network connectivity on epileptiform activity
title The role of network connectivity on epileptiform activity
title_full The role of network connectivity on epileptiform activity
title_fullStr The role of network connectivity on epileptiform activity
title_full_unstemmed The role of network connectivity on epileptiform activity
title_short The role of network connectivity on epileptiform activity
title_sort role of network connectivity on epileptiform activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531347/
https://www.ncbi.nlm.nih.gov/pubmed/34675264
http://dx.doi.org/10.1038/s41598-021-00283-w
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