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Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription
Numbers of nuclear speckles and paraspeckles components have been demonstrated to regulate herpes simplex virus 1 (HSV-1) replication. However, how HSV-1 infection affects the two nuclear bodies, and whether this influence facilitates the expression of viral genes, remains elusive. In the current st...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531360/ https://www.ncbi.nlm.nih.gov/pubmed/34675360 http://dx.doi.org/10.1038/s42003-021-02742-6 |
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author | Li, Kun Wang, Ziqiang |
author_facet | Li, Kun Wang, Ziqiang |
author_sort | Li, Kun |
collection | PubMed |
description | Numbers of nuclear speckles and paraspeckles components have been demonstrated to regulate herpes simplex virus 1 (HSV-1) replication. However, how HSV-1 infection affects the two nuclear bodies, and whether this influence facilitates the expression of viral genes, remains elusive. In the current study, we found that HSV-1 infection leads to a redistribution of speckles and paraspeckles components. Serine/arginine-rich splicing factor 2 (SRSF2), the core component of speckles, was associated with multiple paraspeckles components, including nuclear paraspeckles assembly transcript 1 (NEAT1), PSPC1, and P54nrb, in HSV-1 infected cells. This association coordinates the transcription of viral genes by binding to the promoters of these genes. By association with the enhancer of zeste homolog 2 (EZH2) and P300/CBP complex, NEAT1 and SRSF2 influenced the histone modifications located near viral genes. This study elucidates the interplay between speckles and paraspeckles following HSV-1 infection and provides insight into the mechanisms by which HSV-1 utilizes host cellular nuclear bodies to facilitate its life cycle. |
format | Online Article Text |
id | pubmed-8531360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85313602021-11-15 Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription Li, Kun Wang, Ziqiang Commun Biol Article Numbers of nuclear speckles and paraspeckles components have been demonstrated to regulate herpes simplex virus 1 (HSV-1) replication. However, how HSV-1 infection affects the two nuclear bodies, and whether this influence facilitates the expression of viral genes, remains elusive. In the current study, we found that HSV-1 infection leads to a redistribution of speckles and paraspeckles components. Serine/arginine-rich splicing factor 2 (SRSF2), the core component of speckles, was associated with multiple paraspeckles components, including nuclear paraspeckles assembly transcript 1 (NEAT1), PSPC1, and P54nrb, in HSV-1 infected cells. This association coordinates the transcription of viral genes by binding to the promoters of these genes. By association with the enhancer of zeste homolog 2 (EZH2) and P300/CBP complex, NEAT1 and SRSF2 influenced the histone modifications located near viral genes. This study elucidates the interplay between speckles and paraspeckles following HSV-1 infection and provides insight into the mechanisms by which HSV-1 utilizes host cellular nuclear bodies to facilitate its life cycle. Nature Publishing Group UK 2021-10-21 /pmc/articles/PMC8531360/ /pubmed/34675360 http://dx.doi.org/10.1038/s42003-021-02742-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Kun Wang, Ziqiang Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription |
title | Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription |
title_full | Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription |
title_fullStr | Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription |
title_full_unstemmed | Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription |
title_short | Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription |
title_sort | speckles and paraspeckles coordinate to regulate hsv-1 genes transcription |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531360/ https://www.ncbi.nlm.nih.gov/pubmed/34675360 http://dx.doi.org/10.1038/s42003-021-02742-6 |
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