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Calibration-free NGS quantitation of mutations below 0.01% VAF

Quantitation of rare somatic mutations is essential for basic research and translational clinical applications including minimal residual disease (MRD) detection. Though unique molecular identifier (UMI) has suppressed errors for rare mutation detection, the sequencing depth requirement is high. Her...

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Detalles Bibliográficos
Autores principales:	Dai, Peng, Wu, Lucia Ruojia, Chen, Sherry Xi, Wang, Michael Xiangjiang, Cheng, Lauren Yuxuan, Zhang, Jinny Xuemeng, Hao, Pengying, Yao, Weijie, Zarka, Jabra, Issa, Ghayas C., Kwong, Lawrence, Zhang, David Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531361/ https://www.ncbi.nlm.nih.gov/pubmed/34675197 http://dx.doi.org/10.1038/s41467-021-26308-6

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