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Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome

Considerable evidence suggests that dietary energy levels and gut microbiota are pivotal for animal health and productivity. However, little information exists about the correlations among dietary energy level, performance, and the gut microbiota and metabolome of donkeys. The objective of this stud...

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Autores principales: Zhang, Chongyu, Zhang, Chen, Wang, Yunpeng, Du, Meiyu, Zhang, Guiguo, Lee, Yunkyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531409/
https://www.ncbi.nlm.nih.gov/pubmed/34692802
http://dx.doi.org/10.3389/fvets.2021.694357
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author Zhang, Chongyu
Zhang, Chen
Wang, Yunpeng
Du, Meiyu
Zhang, Guiguo
Lee, Yunkyoung
author_facet Zhang, Chongyu
Zhang, Chen
Wang, Yunpeng
Du, Meiyu
Zhang, Guiguo
Lee, Yunkyoung
author_sort Zhang, Chongyu
collection PubMed
description Considerable evidence suggests that dietary energy levels and gut microbiota are pivotal for animal health and productivity. However, little information exists about the correlations among dietary energy level, performance, and the gut microbiota and metabolome of donkeys. The objective of this study was to investigate the mechanisms by which dietary energy content dictates the growth performance by modulating the intestinal microbiome and metabolome of donkeys. Thirty-six nine-month-old male Dezhou donkeys with similar body weights were randomly assigned to two groups fed low- or high-energy diets (LE or HE). The results showed that donkeys fed HE had increased (p < 0.05) the average daily gain (ADG) and feed efficiency (G/F) compared with those that received LE diet. The gut microbiota in both groups was dominated by the phyla Firmicutes and Bacteroidetes regardless of the dietary energy level. However, feeding HE to donkeys significantly decreased (p < 0.05) the ratio of Firmicutes to Bacteroidetes (F/B). Compared to the LE group, feeding HE specifically increased the abundances of unidentified_Prevotellaceae (p = 0.02) while decreasing the richness of unidentified_Ruminococcaceae (p = 0.05). Compared to the LE group, feeding the HE diet significantly (p < 0.05) upregulated certain metabolic pathways involving the aspartate metabolism and the urea cycle. In addition, the increased bacteria and metabolites in the HE-fed group exhibited a positive correlation with improved growth performance of donkeys. Taken together, feeding the HE diet increased the richness of Prevotellaceae and upregulated growth-related metabolic pathways, which may have contributed to the ameliorated growth performance of donkeys. Thus, it is a recommendable dietary strategy to feed HE diets to fattening donkeys for superior product performance and feed efficiency.
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spelling pubmed-85314092021-10-23 Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome Zhang, Chongyu Zhang, Chen Wang, Yunpeng Du, Meiyu Zhang, Guiguo Lee, Yunkyoung Front Vet Sci Veterinary Science Considerable evidence suggests that dietary energy levels and gut microbiota are pivotal for animal health and productivity. However, little information exists about the correlations among dietary energy level, performance, and the gut microbiota and metabolome of donkeys. The objective of this study was to investigate the mechanisms by which dietary energy content dictates the growth performance by modulating the intestinal microbiome and metabolome of donkeys. Thirty-six nine-month-old male Dezhou donkeys with similar body weights were randomly assigned to two groups fed low- or high-energy diets (LE or HE). The results showed that donkeys fed HE had increased (p < 0.05) the average daily gain (ADG) and feed efficiency (G/F) compared with those that received LE diet. The gut microbiota in both groups was dominated by the phyla Firmicutes and Bacteroidetes regardless of the dietary energy level. However, feeding HE to donkeys significantly decreased (p < 0.05) the ratio of Firmicutes to Bacteroidetes (F/B). Compared to the LE group, feeding HE specifically increased the abundances of unidentified_Prevotellaceae (p = 0.02) while decreasing the richness of unidentified_Ruminococcaceae (p = 0.05). Compared to the LE group, feeding the HE diet significantly (p < 0.05) upregulated certain metabolic pathways involving the aspartate metabolism and the urea cycle. In addition, the increased bacteria and metabolites in the HE-fed group exhibited a positive correlation with improved growth performance of donkeys. Taken together, feeding the HE diet increased the richness of Prevotellaceae and upregulated growth-related metabolic pathways, which may have contributed to the ameliorated growth performance of donkeys. Thus, it is a recommendable dietary strategy to feed HE diets to fattening donkeys for superior product performance and feed efficiency. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531409/ /pubmed/34692802 http://dx.doi.org/10.3389/fvets.2021.694357 Text en Copyright © 2021 Zhang, Zhang, Wang, Du, Zhang and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Zhang, Chongyu
Zhang, Chen
Wang, Yunpeng
Du, Meiyu
Zhang, Guiguo
Lee, Yunkyoung
Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome
title Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome
title_full Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome
title_fullStr Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome
title_full_unstemmed Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome
title_short Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome
title_sort dietary energy level impacts the performance of donkeys by manipulating the gut microbiome and metabolome
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531409/
https://www.ncbi.nlm.nih.gov/pubmed/34692802
http://dx.doi.org/10.3389/fvets.2021.694357
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