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Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections

RNAs are a class of molecules and the majority in eukaryotes are arbitrarily termed non- coding transcripts which are broadly classified as short and long non-coding RNAs. Recently, knowledge of the identification and functions of long non-coding RNAs have continued to accumulate and they are being...

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Autores principales: Olajide, Joshua Seun, Olopade, Bolatito, Cai, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531492/
https://www.ncbi.nlm.nih.gov/pubmed/34692567
http://dx.doi.org/10.3389/fcimb.2021.751523
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author Olajide, Joshua Seun
Olopade, Bolatito
Cai, Jianping
author_facet Olajide, Joshua Seun
Olopade, Bolatito
Cai, Jianping
author_sort Olajide, Joshua Seun
collection PubMed
description RNAs are a class of molecules and the majority in eukaryotes are arbitrarily termed non- coding transcripts which are broadly classified as short and long non-coding RNAs. Recently, knowledge of the identification and functions of long non-coding RNAs have continued to accumulate and they are being recognized as important molecules that regulate parasite-host interface, parasite differentiation, host responses, and disease progression. Herein, we present and integrate the functions of host and parasite long non-coding RNAs during infections within the context of epigenetic re-programming and molecular crosstalk in the course of host-parasite interactions. Also, the modular range of parasite and host long non-coding RNAs in coordinated parasite developmental changes and host immune dynamic landscapes are discussed. We equally canvass the prospects of long non-coding RNAs in disease diagnosis and prognosis. Hindsight and suggestions are offered with the aim that it will bolster our understanding for future works on host and parasite long non-coding RNAs.
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spelling pubmed-85314922021-10-23 Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections Olajide, Joshua Seun Olopade, Bolatito Cai, Jianping Front Cell Infect Microbiol Cellular and Infection Microbiology RNAs are a class of molecules and the majority in eukaryotes are arbitrarily termed non- coding transcripts which are broadly classified as short and long non-coding RNAs. Recently, knowledge of the identification and functions of long non-coding RNAs have continued to accumulate and they are being recognized as important molecules that regulate parasite-host interface, parasite differentiation, host responses, and disease progression. Herein, we present and integrate the functions of host and parasite long non-coding RNAs during infections within the context of epigenetic re-programming and molecular crosstalk in the course of host-parasite interactions. Also, the modular range of parasite and host long non-coding RNAs in coordinated parasite developmental changes and host immune dynamic landscapes are discussed. We equally canvass the prospects of long non-coding RNAs in disease diagnosis and prognosis. Hindsight and suggestions are offered with the aim that it will bolster our understanding for future works on host and parasite long non-coding RNAs. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531492/ /pubmed/34692567 http://dx.doi.org/10.3389/fcimb.2021.751523 Text en Copyright © 2021 Olajide, Olopade and Cai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Olajide, Joshua Seun
Olopade, Bolatito
Cai, Jianping
Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
title Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
title_full Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
title_fullStr Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
title_full_unstemmed Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
title_short Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections
title_sort functional intricacy and symmetry of long non-coding rnas in parasitic infections
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531492/
https://www.ncbi.nlm.nih.gov/pubmed/34692567
http://dx.doi.org/10.3389/fcimb.2021.751523
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