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Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation
Allium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received mor...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531498/ https://www.ncbi.nlm.nih.gov/pubmed/34690775 http://dx.doi.org/10.3389/fphar.2021.738689 |
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author | Cui, Zhen-Yu Han, Xin Jiang, Yu-Chen Dou, Jia-Yi Yao, Kun-Chen Hu, Zhong-He Yuan, Ming-Hui Bao, Xiao-Xue Zhou, Mei-Jie Liu, Yue Lian, Li-Hua Zhang, Xian Nan, Ji-Xing Wu, Yan-Ling |
author_facet | Cui, Zhen-Yu Han, Xin Jiang, Yu-Chen Dou, Jia-Yi Yao, Kun-Chen Hu, Zhong-He Yuan, Ming-Hui Bao, Xiao-Xue Zhou, Mei-Jie Liu, Yue Lian, Li-Hua Zhang, Xian Nan, Ji-Xing Wu, Yan-Ling |
author_sort | Cui, Zhen-Yu |
collection | PubMed |
description | Allium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received more and more attention due to its special nutritional and medicinal value. The present study investigates the effect and potential mechanism of AVL against alcoholic liver disease (ALD). C57BL/6 mice were fed Lieber–DeCarli liquid diet containing 5% ethanol plus a single ethanol gavage (5 g/kg), and followed up with the administration of AVL or silymarin. AML12 cells were stimulated with ethanol and incubated with AVL. AVL significantly reduced serum transaminase and triglycerides in the liver and attenuated histopathological changes caused by ethanol. AVL significantly inhibited SREBP1 and its target genes, regulated lipin 1/2, increased PPARα and its target genes, and decreased PPARγ expression caused by ethanol. In addition, AVL significantly enhanced FXR, LXRs, Sirt1, and AMPK expressions compared with the EtOH group. AVL also inhibited inflammatory factors, NLRP3, and F4/80 and MPO, macrophage and neutrophil markers. In vitro, AVL significantly reduced lipid droplets, lipid metabolism enzymes, and inflammatory factors depending on FXR activation. AVL could ameliorate alcoholic steatohepatitis, lipid deposition and inflammation in ALD by targeting FXR activation. |
format | Online Article Text |
id | pubmed-8531498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85314982021-10-23 Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation Cui, Zhen-Yu Han, Xin Jiang, Yu-Chen Dou, Jia-Yi Yao, Kun-Chen Hu, Zhong-He Yuan, Ming-Hui Bao, Xiao-Xue Zhou, Mei-Jie Liu, Yue Lian, Li-Hua Zhang, Xian Nan, Ji-Xing Wu, Yan-Ling Front Pharmacol Pharmacology Allium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received more and more attention due to its special nutritional and medicinal value. The present study investigates the effect and potential mechanism of AVL against alcoholic liver disease (ALD). C57BL/6 mice were fed Lieber–DeCarli liquid diet containing 5% ethanol plus a single ethanol gavage (5 g/kg), and followed up with the administration of AVL or silymarin. AML12 cells were stimulated with ethanol and incubated with AVL. AVL significantly reduced serum transaminase and triglycerides in the liver and attenuated histopathological changes caused by ethanol. AVL significantly inhibited SREBP1 and its target genes, regulated lipin 1/2, increased PPARα and its target genes, and decreased PPARγ expression caused by ethanol. In addition, AVL significantly enhanced FXR, LXRs, Sirt1, and AMPK expressions compared with the EtOH group. AVL also inhibited inflammatory factors, NLRP3, and F4/80 and MPO, macrophage and neutrophil markers. In vitro, AVL significantly reduced lipid droplets, lipid metabolism enzymes, and inflammatory factors depending on FXR activation. AVL could ameliorate alcoholic steatohepatitis, lipid deposition and inflammation in ALD by targeting FXR activation. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531498/ /pubmed/34690775 http://dx.doi.org/10.3389/fphar.2021.738689 Text en Copyright © 2021 Cui, Han, Jiang, Dou, Yao, Hu, Yuan, Bao, Zhou, Liu, Lian, Zhang, Nan and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Cui, Zhen-Yu Han, Xin Jiang, Yu-Chen Dou, Jia-Yi Yao, Kun-Chen Hu, Zhong-He Yuan, Ming-Hui Bao, Xiao-Xue Zhou, Mei-Jie Liu, Yue Lian, Li-Hua Zhang, Xian Nan, Ji-Xing Wu, Yan-Ling Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
title |
Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
title_full |
Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
title_fullStr |
Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
title_full_unstemmed |
Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
title_short |
Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
title_sort | allium victorialis l. extracts promote activity of fxr to ameliorate alcoholic liver disease: targeting liver lipid deposition and inflammation |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531498/ https://www.ncbi.nlm.nih.gov/pubmed/34690775 http://dx.doi.org/10.3389/fphar.2021.738689 |
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