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Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study

Evidence of the risk factors associated with early-onset colorectal neoplasm from prospective population-based studies is limited. We enrolled 17,293 participants younger than 50 years from the Shanghai colorectal cancer (CRC) screening program cohort. Face-to-face interviews were performed by train...

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Autores principales: Shen, Jie, Wu, Yiling, Mo, Miao, Feng, Xiaoshuang, Zhou, Changming, Wang, Zezhou, Cai, Guoxiang, Zheng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531514/
https://www.ncbi.nlm.nih.gov/pubmed/34692479
http://dx.doi.org/10.3389/fonc.2021.702322
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author Shen, Jie
Wu, Yiling
Mo, Miao
Feng, Xiaoshuang
Zhou, Changming
Wang, Zezhou
Cai, Guoxiang
Zheng, Ying
author_facet Shen, Jie
Wu, Yiling
Mo, Miao
Feng, Xiaoshuang
Zhou, Changming
Wang, Zezhou
Cai, Guoxiang
Zheng, Ying
author_sort Shen, Jie
collection PubMed
description Evidence of the risk factors associated with early-onset colorectal neoplasm from prospective population-based studies is limited. We enrolled 17,293 participants younger than 50 years from the Shanghai colorectal cancer (CRC) screening program cohort. Face-to-face interviews were performed by trained primary care physicians using a standardized questionnaire to collect the information on potential risk factors at baseline entry. Furthermore, 124 cases of early-onset colorectal neoplasm, including six CRC cases and 118 colorectal adenoma (CRA) cases, were detected between 2012 and 2016. Multivariable logistic regression models and restricted cubic spline (RCS) were used to evaluate the risk factors associated with early-onset colorectal neoplasm. We found that sex, body mass index (BMI), and family history of CRC were associated with the early onset of colorectal neoplasm. The RCS model showed a positive dose–response and linear association between BMI and risk of early-onset colorectal neoplasm among young participants (p-overall = 0.19, p-nonlinear = 0.97). The findings indicated that it was beneficial for normal people younger than 50 years to start opportunistic CRC screening. As for those at high risk, increased surveillance is strongly recommended. Further close follow-up is required for research on the underlying causes of early-onset CRC.
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spelling pubmed-85315142021-10-23 Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study Shen, Jie Wu, Yiling Mo, Miao Feng, Xiaoshuang Zhou, Changming Wang, Zezhou Cai, Guoxiang Zheng, Ying Front Oncol Oncology Evidence of the risk factors associated with early-onset colorectal neoplasm from prospective population-based studies is limited. We enrolled 17,293 participants younger than 50 years from the Shanghai colorectal cancer (CRC) screening program cohort. Face-to-face interviews were performed by trained primary care physicians using a standardized questionnaire to collect the information on potential risk factors at baseline entry. Furthermore, 124 cases of early-onset colorectal neoplasm, including six CRC cases and 118 colorectal adenoma (CRA) cases, were detected between 2012 and 2016. Multivariable logistic regression models and restricted cubic spline (RCS) were used to evaluate the risk factors associated with early-onset colorectal neoplasm. We found that sex, body mass index (BMI), and family history of CRC were associated with the early onset of colorectal neoplasm. The RCS model showed a positive dose–response and linear association between BMI and risk of early-onset colorectal neoplasm among young participants (p-overall = 0.19, p-nonlinear = 0.97). The findings indicated that it was beneficial for normal people younger than 50 years to start opportunistic CRC screening. As for those at high risk, increased surveillance is strongly recommended. Further close follow-up is required for research on the underlying causes of early-onset CRC. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531514/ /pubmed/34692479 http://dx.doi.org/10.3389/fonc.2021.702322 Text en Copyright © 2021 Shen, Wu, Mo, Feng, Zhou, Wang, Cai and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shen, Jie
Wu, Yiling
Mo, Miao
Feng, Xiaoshuang
Zhou, Changming
Wang, Zezhou
Cai, Guoxiang
Zheng, Ying
Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
title Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
title_full Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
title_fullStr Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
title_full_unstemmed Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
title_short Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
title_sort risk factors associated with early-onset colorectal neoplasm in chinese youth: a prospective population-based study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531514/
https://www.ncbi.nlm.nih.gov/pubmed/34692479
http://dx.doi.org/10.3389/fonc.2021.702322
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