Autophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities

The ubiquitously expressed transcription factor interferon (IFN) regulatory factor 3 (IRF3) is critical for the induction of antiviral genes, e.g., type-I IFN. In addition to its transcriptional function, IRF3 also activates a nontranscriptional, proapoptotic signaling pathway. While the proapoptoti...

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Detalles Bibliográficos
Autores principales: Glanz, Anna, Chakravarty, Sukanya, Fan, Shumin, Chawla, Karan, Subramanian, Gayatri, Rahman, Tia, Walters, Dean, Chakravarti, Ritu, Chattopadhyay, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531670/
https://www.ncbi.nlm.nih.gov/pubmed/34619149
http://dx.doi.org/10.1016/j.jbc.2021.101274

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