COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks

The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and sim...

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Autores principales: Kgatle, Mankgopo Magdeline, Lawal, Ismaheel Opeyemi, Mashabela, Gabriel, Boshomane, Tebatso Moshoeu Gillian, Koatale, Palesa Caroline, Mahasha, Phetole Walter, Ndlovu, Honest, Vorster, Mariza, Rodrigues, Hosana Gomes, Zeevaart, Jan Rijn, Gordon, Siamon, Moura-Alves, Pedro, Sathekge, Mike Machaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531724/
https://www.ncbi.nlm.nih.gov/pubmed/34691068
http://dx.doi.org/10.3389/fimmu.2021.752380
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author Kgatle, Mankgopo Magdeline
Lawal, Ismaheel Opeyemi
Mashabela, Gabriel
Boshomane, Tebatso Moshoeu Gillian
Koatale, Palesa Caroline
Mahasha, Phetole Walter
Ndlovu, Honest
Vorster, Mariza
Rodrigues, Hosana Gomes
Zeevaart, Jan Rijn
Gordon, Siamon
Moura-Alves, Pedro
Sathekge, Mike Machaba
author_facet Kgatle, Mankgopo Magdeline
Lawal, Ismaheel Opeyemi
Mashabela, Gabriel
Boshomane, Tebatso Moshoeu Gillian
Koatale, Palesa Caroline
Mahasha, Phetole Walter
Ndlovu, Honest
Vorster, Mariza
Rodrigues, Hosana Gomes
Zeevaart, Jan Rijn
Gordon, Siamon
Moura-Alves, Pedro
Sathekge, Mike Machaba
author_sort Kgatle, Mankgopo Magdeline
collection PubMed
description The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.
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spelling pubmed-85317242021-10-23 COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks Kgatle, Mankgopo Magdeline Lawal, Ismaheel Opeyemi Mashabela, Gabriel Boshomane, Tebatso Moshoeu Gillian Koatale, Palesa Caroline Mahasha, Phetole Walter Ndlovu, Honest Vorster, Mariza Rodrigues, Hosana Gomes Zeevaart, Jan Rijn Gordon, Siamon Moura-Alves, Pedro Sathekge, Mike Machaba Front Immunol Immunology The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531724/ /pubmed/34691068 http://dx.doi.org/10.3389/fimmu.2021.752380 Text en Copyright © 2021 Kgatle, Lawal, Mashabela, Boshomane, Koatale, Mahasha, Ndlovu, Vorster, Rodrigues, Zeevaart, Gordon, Moura-Alves and Sathekge https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kgatle, Mankgopo Magdeline
Lawal, Ismaheel Opeyemi
Mashabela, Gabriel
Boshomane, Tebatso Moshoeu Gillian
Koatale, Palesa Caroline
Mahasha, Phetole Walter
Ndlovu, Honest
Vorster, Mariza
Rodrigues, Hosana Gomes
Zeevaart, Jan Rijn
Gordon, Siamon
Moura-Alves, Pedro
Sathekge, Mike Machaba
COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
title COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
title_full COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
title_fullStr COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
title_full_unstemmed COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
title_short COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
title_sort covid-19 is a multi-organ aggressor: epigenetic and clinical marks
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531724/
https://www.ncbi.nlm.nih.gov/pubmed/34691068
http://dx.doi.org/10.3389/fimmu.2021.752380
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