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Speed and Location Both Matter: Antigen Stimulus Dynamics Controls CAR-T Cell Response

Despite the success in B-cell malignancies, chimeric antigen receptor (CAR)-T cell therapies have not yet demonstrated consistent efficacy across all patients and tumor types, particularly against solid tumors. Higher rates of T cell exhaustion are associated with inferior clinical outcomes followin...

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Detalles Bibliográficos
Autores principales:	Liu, Can, Qi, Timothy, Milner, J. Justin, Lu, Yong, Cao, Yanguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531752/ https://www.ncbi.nlm.nih.gov/pubmed/34691062 http://dx.doi.org/10.3389/fimmu.2021.748768

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