Cargando…
Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility
BACKGROUND: The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent....
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531794/ https://www.ncbi.nlm.nih.gov/pubmed/34692853 http://dx.doi.org/10.1155/2021/8727924 |
_version_ | 1784586940579840000 |
---|---|
author | Zhou, Jing Wu, Hao Su, Quan-Xin Shi, Xiao-Kai Tang, Bo-Wen Zhao, Cui-Ping Wang, Hai Chen, Xiao-Ping |
author_facet | Zhou, Jing Wu, Hao Su, Quan-Xin Shi, Xiao-Kai Tang, Bo-Wen Zhao, Cui-Ping Wang, Hai Chen, Xiao-Ping |
author_sort | Zhou, Jing |
collection | PubMed |
description | BACKGROUND: The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent. METHODS: Odds ratios (ORs), 95% confidence intervals (CIs), and combined analysis were used to investigate the effect of CXCR2 variation on cancer risk. Gene Set Enrichment Analysis (GSEA) and enzyme-linked immunosorbent assay (ELISA) were also used to evaluate the expression of CXCR2 in prostate cancer (PCA). RESULTS: Across 11 case-control studies, 4,909 cases and 5,884 controls were involved in the current analysis. Individuals with a TT genotype were associated with increased risk of digestive cancer, compared to those with a TC+CC genotype (OR = 1.16, 95%CI = 1.02-1.31, P = 0.025). Individuals carrying the TT genotype had a 39% higher risk of urinary cancer than those carrying CC genotype (OR = 1.39, 95%CI = 1.04-1.87, P = 0.025). Individuals with a TT genotype showed a 56% augmented breast cancer risk, compared to those with a CC genotype (OR = 1.56, 95%CI = 1.03-2.35, P = 0.034). It was found that CXCR2 expression was downregulated in PCA. Compared with PCA subjects carrying the CC genotype, the expression of CXCR2 was decreased in patients with the TT genotype. CONCLUSIONS: The CXCR2 C1208T variation was associated with elevated risk of urinary, breast, and digestive cancer. However, the C1208T polymorphism was correlated with attenuated risk of lung cancer. |
format | Online Article Text |
id | pubmed-8531794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85317942021-10-23 Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility Zhou, Jing Wu, Hao Su, Quan-Xin Shi, Xiao-Kai Tang, Bo-Wen Zhao, Cui-Ping Wang, Hai Chen, Xiao-Ping J Immunol Res Research Article BACKGROUND: The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent. METHODS: Odds ratios (ORs), 95% confidence intervals (CIs), and combined analysis were used to investigate the effect of CXCR2 variation on cancer risk. Gene Set Enrichment Analysis (GSEA) and enzyme-linked immunosorbent assay (ELISA) were also used to evaluate the expression of CXCR2 in prostate cancer (PCA). RESULTS: Across 11 case-control studies, 4,909 cases and 5,884 controls were involved in the current analysis. Individuals with a TT genotype were associated with increased risk of digestive cancer, compared to those with a TC+CC genotype (OR = 1.16, 95%CI = 1.02-1.31, P = 0.025). Individuals carrying the TT genotype had a 39% higher risk of urinary cancer than those carrying CC genotype (OR = 1.39, 95%CI = 1.04-1.87, P = 0.025). Individuals with a TT genotype showed a 56% augmented breast cancer risk, compared to those with a CC genotype (OR = 1.56, 95%CI = 1.03-2.35, P = 0.034). It was found that CXCR2 expression was downregulated in PCA. Compared with PCA subjects carrying the CC genotype, the expression of CXCR2 was decreased in patients with the TT genotype. CONCLUSIONS: The CXCR2 C1208T variation was associated with elevated risk of urinary, breast, and digestive cancer. However, the C1208T polymorphism was correlated with attenuated risk of lung cancer. Hindawi 2021-10-14 /pmc/articles/PMC8531794/ /pubmed/34692853 http://dx.doi.org/10.1155/2021/8727924 Text en Copyright © 2021 Jing Zhou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Jing Wu, Hao Su, Quan-Xin Shi, Xiao-Kai Tang, Bo-Wen Zhao, Cui-Ping Wang, Hai Chen, Xiao-Ping Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility |
title | Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility |
title_full | Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility |
title_fullStr | Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility |
title_full_unstemmed | Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility |
title_short | Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility |
title_sort | impacts of chemokine (c-x-c motif) receptor 2 c1208t polymorphism on cancer susceptibility |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531794/ https://www.ncbi.nlm.nih.gov/pubmed/34692853 http://dx.doi.org/10.1155/2021/8727924 |
work_keys_str_mv | AT zhoujing impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT wuhao impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT suquanxin impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT shixiaokai impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT tangbowen impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT zhaocuiping impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT wanghai impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility AT chenxiaoping impactsofchemokinecxcmotifreceptor2c1208tpolymorphismoncancersusceptibility |