The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes

The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In...

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Detalles Bibliográficos
Autores principales: Camarillo, Rosa, Jimeno, Sonia, Huertas, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531813/
https://www.ncbi.nlm.nih.gov/pubmed/34691154
http://dx.doi.org/10.3389/fgene.2021.742434
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author Camarillo, Rosa
Jimeno, Sonia
Huertas, Pablo
author_facet Camarillo, Rosa
Jimeno, Sonia
Huertas, Pablo
author_sort Camarillo, Rosa
collection PubMed
description The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.
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spelling pubmed-85318132021-10-23 The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes Camarillo, Rosa Jimeno, Sonia Huertas, Pablo Front Genet Genetics The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR. Frontiers Media S.A. 2021-10-08 /pmc/articles/PMC8531813/ /pubmed/34691154 http://dx.doi.org/10.3389/fgene.2021.742434 Text en Copyright © 2021 Camarillo, Jimeno and Huertas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Camarillo, Rosa
Jimeno, Sonia
Huertas, Pablo
The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_full The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_fullStr The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_full_unstemmed The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_short The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_sort effect of atypical nucleic acids structures in dna double strand break repair: a tale of r-loops and g-quadruplexes
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531813/
https://www.ncbi.nlm.nih.gov/pubmed/34691154
http://dx.doi.org/10.3389/fgene.2021.742434
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