Cargando…

Triptolide Attenuates Neuropathic Pain by Regulating Microglia Polarization through the CCL2/CCR2 Axis

Triptolide (T10) is a common anti-inflammatory and analgesic drug. However, the activation of microglia and elimination of the corresponding inflammatory response are new targets for the treatment of neuropathic pain. Chemokine CCL (CCL2) is a key mediator for activating microglia. In this study, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bao, Xubin, Chen, Cai, Yuan, Liyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531820/ https://www.ncbi.nlm.nih.gov/pubmed/34691228 http://dx.doi.org/10.1155/2021/8985721

Ejemplares similares

Chemokine CCL7 mediates trigeminal neuropathic pain via CCR2/CCR3-ERK pathway in the trigeminal ganglion of mice
por: Zhu, Lin-Peng, et al.
Publicado: (2023)

Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis
por: Zhang, Chunzhi, et al.
Publicado: (2022)

Roles of CCL2-CCR2 Axis in the Tumor Microenvironment
por: Kadomoto, Suguru, et al.
Publicado: (2021)

Targeting the CCL2-CCR2 axis in depressive disorders
por: Curzytek, Katarzyna, et al.
Publicado: (2021)

Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain
por: Zhang, Zhi-Jun, et al.
Publicado: (2012)

MicroRNA-183 attenuates osteoarthritic pain by inhibiting the TGFα-mediated CCL2/CCR2 signalling axis
por: Tao, Zirong, et al.
Publicado: (2021)

Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway
por: Hu, Yahui, et al.
Publicado: (2017)

Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding()
por: Roblek, Marko, et al.
Publicado: (2016)

Targeting the CCL2-CCR2 signaling axis in cancer metastasis
por: Lim, Su Yin, et al.
Publicado: (2016)

Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats
por: Gao, Pengfei, et al.
Publicado: (2021)

CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats
por: Zhang, Anke, et al.
Publicado: (2022)

miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis
por: Jin, Xing, et al.
Publicado: (2023)

RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization
por: Tan, Ying, et al.
Publicado: (2022)

The CCL5/CCR5 Axis in Cancer Progression
por: Aldinucci, Donatella, et al.
Publicado: (2020)

The CCL20-CCR6 Axis in Cancer Progression
por: Kadomoto, Suguru, et al.
Publicado: (2020)

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
por: Xu, Maosen, et al.
Publicado: (2021)

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain
por: Hajal, Cynthia, et al.
Publicado: (2021)

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
por: Zhang, Haixia, et al.
Publicado: (2022)

Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2022)

The intricate role of CCL5/CCR5 axis in Alzheimer disease
por: Ma, Weijiang, et al.
Publicado: (2023)

Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain
por: Biber, Knut, et al.
Publicado: (2014)

Relevance of CCL3/CCR5 axis in oral carcinogenesis
por: da Silva, Janine Mayra, et al.
Publicado: (2017)

Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis
por: Izhak, Liat, et al.
Publicado: (2012)

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?
por: Fei, Liyang, et al.
Publicado: (2021)

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity
por: Dansereau, Marc-André, et al.
Publicado: (2021)

CCL2, CCR2 Gene Variants and CCL2, CCR2 Serum Levels Association with Age-Related Macular Degeneration
por: Gudauskiene, Gaile, et al.
Publicado: (2022)

Microglia: sculptors of neuropathic pain?
por: Ward, Harry, et al.
Publicado: (2020)

Role of Microglia in Neuropathic Pain
por: Karavis, Miltiades Y, et al.
Publicado: (2023)

The synergistic effect of treatment with triptolide and MK-801 in the rat neuropathic pain model
por: Wang, Jian, et al.
Publicado: (2017)

CCL2/CCR2 signaling in cancer pathogenesis
por: Hao, Qiongyu, et al.
Publicado: (2020)

Correction: Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis
por: Izhak, Liat, et al.
Publicado: (2018)

Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
por: Ben-Yehuda, Hila, et al.
Publicado: (2021)

Cytokine CCL5 and Receptor CCR5 Axis in Glioblastoma Multiforme
por: Kranjc, Miha Koprivnikar, et al.
Publicado: (2019)

The Role of CCL20-CCR6 Axis in Ovarian Cancer Metastasis
por: Liu, Wan, et al.
Publicado: (2020)

CCL17‐CCR4 axis contributes to the onset of vitiligo in mice
por: Li, He, et al.
Publicado: (2021)

CCL5/CCR5 axis in human diseases and related treatments
por: Zeng, Zhen, et al.
Publicado: (2021)

Endothelial cell-derived CCL15 mediates the transmigration of fibrocytes through the CCL15-CCR1 axis in vitro
por: Pang, Nan, et al.
Publicado: (2020)

Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis
por: Kikuchi, Tetsuhiro, et al.
Publicado: (2019)

CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma
por: Geraldo, Luiz Henrique, et al.
Publicado: (2023)

Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization
por: Yuan, Jiaqi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qrtnnulcc3rlvhtnai6kvftgni