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The impact of obesity on adipocyte-derived extracellular vesicles
Recently, the emerging roles of adipocyte-derived extracellular vesicles (EVs) linking obesity and its comorbidities have been recognized. In obese subjects, adipocytes are having hypertrophic growth and are under stressed. The dysfunction adipocytes dysregulate the assembly of the biological compon...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531905/ https://www.ncbi.nlm.nih.gov/pubmed/34677643 http://dx.doi.org/10.1007/s00018-021-03973-w |
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author | Kwan, Hiu Yee Chen, Minting Xu, Keyang Chen, Baisen |
author_facet | Kwan, Hiu Yee Chen, Minting Xu, Keyang Chen, Baisen |
author_sort | Kwan, Hiu Yee |
collection | PubMed |
description | Recently, the emerging roles of adipocyte-derived extracellular vesicles (EVs) linking obesity and its comorbidities have been recognized. In obese subjects, adipocytes are having hypertrophic growth and are under stressed. The dysfunction adipocytes dysregulate the assembly of the biological components in the EVs including exosomes. This article critically reviews the current findings on the impact of obesity on the exosomal cargo contents that induce the pathophysiological changes. Besides, this review also summarizes the understanding on how obesity affects the biogenesis of adipocyte-derived exosomes and the exosome secretion. Furthermore, the differences of the exosomal contents in different adipose depots, and the impact of obesity on the exosomes that are derived from the stromal vascular fraction such as the adipose tissue macrophages and adipocyte-derived stem cells will also be discussed. The current development and potential application of exosome-based therapy will be summarized. This review provides crucial information for the design of novel exosome-based therapy for the treatment of obesity and its comorbidities. |
format | Online Article Text |
id | pubmed-8531905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-85319052021-10-22 The impact of obesity on adipocyte-derived extracellular vesicles Kwan, Hiu Yee Chen, Minting Xu, Keyang Chen, Baisen Cell Mol Life Sci Review Recently, the emerging roles of adipocyte-derived extracellular vesicles (EVs) linking obesity and its comorbidities have been recognized. In obese subjects, adipocytes are having hypertrophic growth and are under stressed. The dysfunction adipocytes dysregulate the assembly of the biological components in the EVs including exosomes. This article critically reviews the current findings on the impact of obesity on the exosomal cargo contents that induce the pathophysiological changes. Besides, this review also summarizes the understanding on how obesity affects the biogenesis of adipocyte-derived exosomes and the exosome secretion. Furthermore, the differences of the exosomal contents in different adipose depots, and the impact of obesity on the exosomes that are derived from the stromal vascular fraction such as the adipose tissue macrophages and adipocyte-derived stem cells will also be discussed. The current development and potential application of exosome-based therapy will be summarized. This review provides crucial information for the design of novel exosome-based therapy for the treatment of obesity and its comorbidities. Springer International Publishing 2021-10-22 2021 /pmc/articles/PMC8531905/ /pubmed/34677643 http://dx.doi.org/10.1007/s00018-021-03973-w Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Kwan, Hiu Yee Chen, Minting Xu, Keyang Chen, Baisen The impact of obesity on adipocyte-derived extracellular vesicles |
title | The impact of obesity on adipocyte-derived extracellular vesicles |
title_full | The impact of obesity on adipocyte-derived extracellular vesicles |
title_fullStr | The impact of obesity on adipocyte-derived extracellular vesicles |
title_full_unstemmed | The impact of obesity on adipocyte-derived extracellular vesicles |
title_short | The impact of obesity on adipocyte-derived extracellular vesicles |
title_sort | impact of obesity on adipocyte-derived extracellular vesicles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531905/ https://www.ncbi.nlm.nih.gov/pubmed/34677643 http://dx.doi.org/10.1007/s00018-021-03973-w |
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