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Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran

BACKGROUND Hepatitis B and C virus (HBV and HCV) infections rank among the most frequent infectious diseases with a rising worldwide burden. However, their epidemiology and risk factors are understudied in many regions, including Iran. METHODS This study was conducted as part of the Pars Cohort Stud...

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Autores principales: Hariri, Sanam, Davari, Sabereh, Malekzadeh, Zeinab, Mohammadi, Zahra, Masoudi, Sahar, Gandomkar, Abdullah, Amini-Kafiabad, Sedigheh, Maghsoudloo, Mahtab, Merat, Shahin, Poustchi, Hossein, Malekzadeh, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531928/
https://www.ncbi.nlm.nih.gov/pubmed/34712446
http://dx.doi.org/10.34172/mejdd.2021.211
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author Hariri, Sanam
Davari, Sabereh
Malekzadeh, Zeinab
Mohammadi, Zahra
Masoudi, Sahar
Gandomkar, Abdullah
Amini-Kafiabad, Sedigheh
Maghsoudloo, Mahtab
Merat, Shahin
Poustchi, Hossein
Malekzadeh, Fatemeh
author_facet Hariri, Sanam
Davari, Sabereh
Malekzadeh, Zeinab
Mohammadi, Zahra
Masoudi, Sahar
Gandomkar, Abdullah
Amini-Kafiabad, Sedigheh
Maghsoudloo, Mahtab
Merat, Shahin
Poustchi, Hossein
Malekzadeh, Fatemeh
author_sort Hariri, Sanam
collection PubMed
description BACKGROUND Hepatitis B and C virus (HBV and HCV) infections rank among the most frequent infectious diseases with a rising worldwide burden. However, their epidemiology and risk factors are understudied in many regions, including Iran. METHODS This study was conducted as part of the Pars Cohort Study (PCS) in Valashahr district, Fars province (2012-2014). Participants received venipuncture for HBsAg and HCV antibody, followed by Polymerase Chain Reaction (PCR) testing. All infected people and their comparison groups completed a risk assessment questionnaire. RESULTS Overall, 9,269 people participated in the study; the majority were women and of Fars ethnicity. Prevalence of HBsAg and HCV antibody was 2.3% (n = 215) and 0.3% (n = 26), from whom 23% (n = 47) and 13% (n = 3) had indications for treatment, respectively. During follow-up, among HBsAg-positive individuals who were not on treatment, 62% tested negative for HBsAg, and in 2% HBV DNA had risen to treatment levels. Risk factors for HBV infection were illiteracy [OR = 3.43, 95% CI = 1.1, 10.3], and Turk ethnicity compared to Fars [OR = 1.58, 95% CI = 1.1, 2.3]. History of blood transfusion [OR = 2.00, 95% CI = 1.1, 3.5] and history of drug use [OR = 2.85, 95% CI = 1.1, 7.4] were associated with HCV infection, after adjustment. CONCLUSION Further epidemiological studies are needed to identify at-risk populations in different regions. Preventive interventions, including educational programs and transfusion safety strategies, are crucial for reducing the hepatitis burden.
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spelling pubmed-85319282021-10-27 Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran Hariri, Sanam Davari, Sabereh Malekzadeh, Zeinab Mohammadi, Zahra Masoudi, Sahar Gandomkar, Abdullah Amini-Kafiabad, Sedigheh Maghsoudloo, Mahtab Merat, Shahin Poustchi, Hossein Malekzadeh, Fatemeh Middle East J Dig Dis Original Article BACKGROUND Hepatitis B and C virus (HBV and HCV) infections rank among the most frequent infectious diseases with a rising worldwide burden. However, their epidemiology and risk factors are understudied in many regions, including Iran. METHODS This study was conducted as part of the Pars Cohort Study (PCS) in Valashahr district, Fars province (2012-2014). Participants received venipuncture for HBsAg and HCV antibody, followed by Polymerase Chain Reaction (PCR) testing. All infected people and their comparison groups completed a risk assessment questionnaire. RESULTS Overall, 9,269 people participated in the study; the majority were women and of Fars ethnicity. Prevalence of HBsAg and HCV antibody was 2.3% (n = 215) and 0.3% (n = 26), from whom 23% (n = 47) and 13% (n = 3) had indications for treatment, respectively. During follow-up, among HBsAg-positive individuals who were not on treatment, 62% tested negative for HBsAg, and in 2% HBV DNA had risen to treatment levels. Risk factors for HBV infection were illiteracy [OR = 3.43, 95% CI = 1.1, 10.3], and Turk ethnicity compared to Fars [OR = 1.58, 95% CI = 1.1, 2.3]. History of blood transfusion [OR = 2.00, 95% CI = 1.1, 3.5] and history of drug use [OR = 2.85, 95% CI = 1.1, 7.4] were associated with HCV infection, after adjustment. CONCLUSION Further epidemiological studies are needed to identify at-risk populations in different regions. Preventive interventions, including educational programs and transfusion safety strategies, are crucial for reducing the hepatitis burden. Iranian Association of Gastroerterology and Hepatology 2021-04 2021-05-29 /pmc/articles/PMC8531928/ /pubmed/34712446 http://dx.doi.org/10.34172/mejdd.2021.211 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/ This work is published by Middle East Journal of Digestive Diseaes as an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Hariri, Sanam
Davari, Sabereh
Malekzadeh, Zeinab
Mohammadi, Zahra
Masoudi, Sahar
Gandomkar, Abdullah
Amini-Kafiabad, Sedigheh
Maghsoudloo, Mahtab
Merat, Shahin
Poustchi, Hossein
Malekzadeh, Fatemeh
Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
title Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
title_full Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
title_fullStr Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
title_full_unstemmed Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
title_short Prevalence of Hepatitis B and C Infections and Associated Risk Factors in Pars Cohort Study, Southern Iran
title_sort prevalence of hepatitis b and c infections and associated risk factors in pars cohort study, southern iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531928/
https://www.ncbi.nlm.nih.gov/pubmed/34712446
http://dx.doi.org/10.34172/mejdd.2021.211
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