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Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature

Colonic malakoplakia is a rare chronic granulomatous disease that can involve many organs such as the lung, brain, pancreas, bone, adrenal glands, and genitourinary tract. The most common site of involvement outside the genitourinary tract is the gastrointestinal tract. We report a case of colonic m...

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Autores principales: Taher, Mohammad, Shahsia, Reza, Ebrahimi Daryani, Nasser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531935/
https://www.ncbi.nlm.nih.gov/pubmed/34712442
http://dx.doi.org/10.34172/mejdd.2021.207
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author Taher, Mohammad
Shahsia, Reza
Ebrahimi Daryani, Nasser
author_facet Taher, Mohammad
Shahsia, Reza
Ebrahimi Daryani, Nasser
author_sort Taher, Mohammad
collection PubMed
description Colonic malakoplakia is a rare chronic granulomatous disease that can involve many organs such as the lung, brain, pancreas, bone, adrenal glands, and genitourinary tract. The most common site of involvement outside the genitourinary tract is the gastrointestinal tract. We report a case of colonic malakoplakia who presented with unintentional weight loss, abdominal pain, and chronic diarrhea. There was a history of lupus nephritis and Sjogren disease, receiving various immunosuppressive drugs. Physical examination other than pallor was unremarkable in this patient, but colonoscopy revealed multiple polyps in the rectum with a cobblestone appearance in the cecum. The histopathological assessment showed infiltration of numerous lymphoplasma cells and neutrophils in the lamina propria, and rare Michaelis-Gutmann bodies were seen in foamy epithelioid histiocytes. These findings are suggestive of malakoplakia. We treated the patient with tetracycline, and after 3 months of follow-up, clinical improvement was achieved.
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spelling pubmed-85319352021-10-27 Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature Taher, Mohammad Shahsia, Reza Ebrahimi Daryani, Nasser Middle East J Dig Dis Case Report Colonic malakoplakia is a rare chronic granulomatous disease that can involve many organs such as the lung, brain, pancreas, bone, adrenal glands, and genitourinary tract. The most common site of involvement outside the genitourinary tract is the gastrointestinal tract. We report a case of colonic malakoplakia who presented with unintentional weight loss, abdominal pain, and chronic diarrhea. There was a history of lupus nephritis and Sjogren disease, receiving various immunosuppressive drugs. Physical examination other than pallor was unremarkable in this patient, but colonoscopy revealed multiple polyps in the rectum with a cobblestone appearance in the cecum. The histopathological assessment showed infiltration of numerous lymphoplasma cells and neutrophils in the lamina propria, and rare Michaelis-Gutmann bodies were seen in foamy epithelioid histiocytes. These findings are suggestive of malakoplakia. We treated the patient with tetracycline, and after 3 months of follow-up, clinical improvement was achieved. Iranian Association of Gastroerterology and Hepatology 2021-01 2021-03-02 /pmc/articles/PMC8531935/ /pubmed/34712442 http://dx.doi.org/10.34172/mejdd.2021.207 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/ This work is published by Middle East Journal of Digestive Diseaes as an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Case Report
Taher, Mohammad
Shahsia, Reza
Ebrahimi Daryani, Nasser
Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature
title Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature
title_full Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature
title_fullStr Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature
title_full_unstemmed Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature
title_short Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature
title_sort malakoplakia as a rare cause of diarrhea: case presentation and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531935/
https://www.ncbi.nlm.nih.gov/pubmed/34712442
http://dx.doi.org/10.34172/mejdd.2021.207
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