The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19

BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreas...

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Detalles Bibliográficos
Autores principales: AbdelMassih, Antoine, Hozaien, Rafeef, El Shershaby, Meryam, Kamel, Aya, Ismail, Habiba-Allah, Arsanyous, Mariem, El-Husseiny, Nadine, Khalil, Noha, Naeem, Youstina, Fouda, Raghda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532099/
https://www.ncbi.nlm.nih.gov/pubmed/34677688
http://dx.doi.org/10.1186/s43141-021-00249-5
Descripción
Sumario:BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreases cytosolic calcium levels, which impairs the action of Furin. SARS-CoV-2 uses Furin to replicate in the respiratory tract. SHORT CONCLUSION: Inhaled nitric oxide could decrease the viral load in the upper respiratory tract, abort clinically symptomatic infection, and prevent subsequent complications. Nitric oxide might be a tool for post-exposure chemoprophylaxis in at-risk groups, especially medical personnel.

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