The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19

BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreas...

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Autores principales: AbdelMassih, Antoine, Hozaien, Rafeef, El Shershaby, Meryam, Kamel, Aya, Ismail, Habiba-Allah, Arsanyous, Mariem, El-Husseiny, Nadine, Khalil, Noha, Naeem, Youstina, Fouda, Raghda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532099/
https://www.ncbi.nlm.nih.gov/pubmed/34677688
http://dx.doi.org/10.1186/s43141-021-00249-5
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author AbdelMassih, Antoine
Hozaien, Rafeef
El Shershaby, Meryam
Kamel, Aya
Ismail, Habiba-Allah
Arsanyous, Mariem
El-Husseiny, Nadine
Khalil, Noha
Naeem, Youstina
Fouda, Raghda
author_facet AbdelMassih, Antoine
Hozaien, Rafeef
El Shershaby, Meryam
Kamel, Aya
Ismail, Habiba-Allah
Arsanyous, Mariem
El-Husseiny, Nadine
Khalil, Noha
Naeem, Youstina
Fouda, Raghda
author_sort AbdelMassih, Antoine
collection PubMed
description BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreases cytosolic calcium levels, which impairs the action of Furin. SARS-CoV-2 uses Furin to replicate in the respiratory tract. SHORT CONCLUSION: Inhaled nitric oxide could decrease the viral load in the upper respiratory tract, abort clinically symptomatic infection, and prevent subsequent complications. Nitric oxide might be a tool for post-exposure chemoprophylaxis in at-risk groups, especially medical personnel.
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spelling pubmed-85320992021-10-22 The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19 AbdelMassih, Antoine Hozaien, Rafeef El Shershaby, Meryam Kamel, Aya Ismail, Habiba-Allah Arsanyous, Mariem El-Husseiny, Nadine Khalil, Noha Naeem, Youstina Fouda, Raghda J Genet Eng Biotechnol Short Communications BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreases cytosolic calcium levels, which impairs the action of Furin. SARS-CoV-2 uses Furin to replicate in the respiratory tract. SHORT CONCLUSION: Inhaled nitric oxide could decrease the viral load in the upper respiratory tract, abort clinically symptomatic infection, and prevent subsequent complications. Nitric oxide might be a tool for post-exposure chemoprophylaxis in at-risk groups, especially medical personnel. Springer Berlin Heidelberg 2021-10-22 /pmc/articles/PMC8532099/ /pubmed/34677688 http://dx.doi.org/10.1186/s43141-021-00249-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communications
AbdelMassih, Antoine
Hozaien, Rafeef
El Shershaby, Meryam
Kamel, Aya
Ismail, Habiba-Allah
Arsanyous, Mariem
El-Husseiny, Nadine
Khalil, Noha
Naeem, Youstina
Fouda, Raghda
The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19
title The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19
title_full The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19
title_fullStr The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19
title_full_unstemmed The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19
title_short The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19
title_sort potential role of inhaled nitric oxide for postexposure chemoprophylaxis of covid-19
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532099/
https://www.ncbi.nlm.nih.gov/pubmed/34677688
http://dx.doi.org/10.1186/s43141-021-00249-5
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