Cargando…
Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry
[Image: see text] The availability of tools to generate homogeneous and stable antibody conjugates without recombinant DNA technology is a valuable asset in fields spanning from in vitro diagnostics to in vivo imaging and therapeutics. We present here a general approach for the conjugation to human...
Autores principales: | Bruins, Jorick J., Damen, Johannes A. M., Wijdeven, Marloes A., Lelieveldt, Lianne P. W. M., van Delft, Floris L., Albada, Bauke |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532111/ https://www.ncbi.nlm.nih.gov/pubmed/34519477 http://dx.doi.org/10.1021/acs.bioconjchem.1c00351 |
Ejemplares similares
-
Highly Efficient Mono-Functionalization of Knob-in-Hole
Antibodies with Strain-Promoted Click Chemistry
por: Bruins, Jorick J., et al.
Publicado: (2019) -
Oxidation-Induced “One-Pot” Click Chemistry
por: Albada, Bauke, et al.
Publicado: (2021) -
ortho‐Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization
por: Bruins, Jorick J., et al.
Publicado: (2017) -
Inducible, Site-Specific Protein Labeling by Tyrosine
Oxidation–Strain-Promoted (4 + 2) Cycloaddition
por: Bruins, Jorick J., et al.
Publicado: (2017) -
Enzymatic glycan remodeling–metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering
por: Wijdeven, Marloes A., et al.
Publicado: (2022)