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Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein–Protein Complexes

[Image: see text] Protein–protein interactions (PPIs) have evolved to display binding affinities that can support their function. As such, cognate and noncognate PPIs could be highly similar structurally but exhibit huge differences in binding affinities. To understand this phenomenon, we study thre...

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Detalles Bibliográficos
Autores principales:	Heyne, Michael, Shirian, Jason, Cohen, Itay, Peleg, Yoav, Radisky, Evette S., Papo, Niv, Shifman, Julia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532158/ https://www.ncbi.nlm.nih.gov/pubmed/34609866 http://dx.doi.org/10.1021/jacs.1c08707

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