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Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report
BACKGROUND: Langerhans cell histiocytosis (LCH) is a heterogeneous disease with diverse clinical manifestations. Abdominal organ involvement is rare. Early diagnosis and active treatment are needed. The purpose of this article is to enable readers to have a better knowledge of LCH and prevent misdia...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532305/ https://www.ncbi.nlm.nih.gov/pubmed/34686179 http://dx.doi.org/10.1186/s12887-021-02921-8 |
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author | Lv, Xintong Wang, Libo Pi, Zhuang Zhang, Chunyan |
author_facet | Lv, Xintong Wang, Libo Pi, Zhuang Zhang, Chunyan |
author_sort | Lv, Xintong |
collection | PubMed |
description | BACKGROUND: Langerhans cell histiocytosis (LCH) is a heterogeneous disease with diverse clinical manifestations. Abdominal organ involvement is rare. Early diagnosis and active treatment are needed. The purpose of this article is to enable readers to have a better knowledge of LCH and prevent misdiagnosis. CASE PRESENTATION: A 2-month-old boy had diarrhea, hematochezia, and a rash, and was diagnosed as having a cow milk protein allergy (CMPA). He was given an amino acid-based formula, but there was no sign of improvement in his condition. The patient then had a skin biopsy and was diagnosed as having multisystem Langerhans cell histiocytosis (MS-LCH). The general condition of the child deteriorated after the first two doses of chemotherapy, and the child died. CONCLUSIONS: MS-LCH is a protracted and progressive condition with poor prognosis. Early diagnosis and treatment are essential for survival. If a child has chronic diarrhea and hematochezia in the presence of a characteristic rash, the pediatrician should consider the possibility of this disease to avoid misdiagnosis. |
format | Online Article Text |
id | pubmed-8532305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85323052021-10-25 Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report Lv, Xintong Wang, Libo Pi, Zhuang Zhang, Chunyan BMC Pediatr Case Report BACKGROUND: Langerhans cell histiocytosis (LCH) is a heterogeneous disease with diverse clinical manifestations. Abdominal organ involvement is rare. Early diagnosis and active treatment are needed. The purpose of this article is to enable readers to have a better knowledge of LCH and prevent misdiagnosis. CASE PRESENTATION: A 2-month-old boy had diarrhea, hematochezia, and a rash, and was diagnosed as having a cow milk protein allergy (CMPA). He was given an amino acid-based formula, but there was no sign of improvement in his condition. The patient then had a skin biopsy and was diagnosed as having multisystem Langerhans cell histiocytosis (MS-LCH). The general condition of the child deteriorated after the first two doses of chemotherapy, and the child died. CONCLUSIONS: MS-LCH is a protracted and progressive condition with poor prognosis. Early diagnosis and treatment are essential for survival. If a child has chronic diarrhea and hematochezia in the presence of a characteristic rash, the pediatrician should consider the possibility of this disease to avoid misdiagnosis. BioMed Central 2021-10-22 /pmc/articles/PMC8532305/ /pubmed/34686179 http://dx.doi.org/10.1186/s12887-021-02921-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Lv, Xintong Wang, Libo Pi, Zhuang Zhang, Chunyan Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
title | Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
title_full | Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
title_fullStr | Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
title_full_unstemmed | Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
title_short | Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
title_sort | langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532305/ https://www.ncbi.nlm.nih.gov/pubmed/34686179 http://dx.doi.org/10.1186/s12887-021-02921-8 |
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