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Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study

OBJECTIVES: The aim of this study was to assess the seroprevalence and associated factors of cytomegalovirus (CMV) among pregnant women in Southern Ethiopia. DESIGN: Cross-sectional study. SETTING: The study was conducted in Hawassa University comprehensive and specialised hospital. Hawassa, Souther...

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Autores principales: Zenebe, Mengistu Hailemariam, Mekonnen, Zeleke, Loha, Eskindir, Padalko, Elizaveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532544/
https://www.ncbi.nlm.nih.gov/pubmed/34675017
http://dx.doi.org/10.1136/bmjopen-2021-051390
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author Zenebe, Mengistu Hailemariam
Mekonnen, Zeleke
Loha, Eskindir
Padalko, Elizaveta
author_facet Zenebe, Mengistu Hailemariam
Mekonnen, Zeleke
Loha, Eskindir
Padalko, Elizaveta
author_sort Zenebe, Mengistu Hailemariam
collection PubMed
description OBJECTIVES: The aim of this study was to assess the seroprevalence and associated factors of cytomegalovirus (CMV) among pregnant women in Southern Ethiopia. DESIGN: Cross-sectional study. SETTING: The study was conducted in Hawassa University comprehensive and specialised hospital. Hawassa, Southern Ethiopia. PARTICIPANTS: A total of 600 consecutive pregnant women attending the delivery ward were recruited for the study from August to October 2020. OUTCOME MEASURES: The study assessed the rate of maternal anti-CMV IgG and IgM antibodies. The association of obstetric history, sociodemographic and behavioural characteristics with seropositivity of CMV was also evaluated based on the collected data using structured questioners. RESULTS: Seropositivity for CMV IgM antibodies was 8.2% (49/600) (95% CI 6% to 10.5%), whereas the CMV IgG was 88.7% (532/600), (95% CI 89.5% to 94.0%). Seroprevalence of CMV IgM was higher in women of older age, currently unmarried, having nursery schooled children and with any of the detected curable sexually transmitted infections, while seroprevalence of CMV IgG was significantly associated only with women having nursery schooled children. Seroprevalence was not significantly associated with previous adverse pregnancy outcome, gravidity, being a child daycare occupant mother and newborn birth weight. CONCLUSION: In the present study, we identified a high rate of CMV IgM and CMV IgG seroprevalence among pregnant women in Southern Ethiopia. Given that there is no existing CMV diagnosis, special attention should be designed to pregnant women in parallel to the existing antenatal care facility. Besides, training healthcare professionals will support awareness conception among pregnant women concerning the sequels of CMV infection during pregnancy.
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spelling pubmed-85325442021-11-04 Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study Zenebe, Mengistu Hailemariam Mekonnen, Zeleke Loha, Eskindir Padalko, Elizaveta BMJ Open Obstetrics and Gynaecology OBJECTIVES: The aim of this study was to assess the seroprevalence and associated factors of cytomegalovirus (CMV) among pregnant women in Southern Ethiopia. DESIGN: Cross-sectional study. SETTING: The study was conducted in Hawassa University comprehensive and specialised hospital. Hawassa, Southern Ethiopia. PARTICIPANTS: A total of 600 consecutive pregnant women attending the delivery ward were recruited for the study from August to October 2020. OUTCOME MEASURES: The study assessed the rate of maternal anti-CMV IgG and IgM antibodies. The association of obstetric history, sociodemographic and behavioural characteristics with seropositivity of CMV was also evaluated based on the collected data using structured questioners. RESULTS: Seropositivity for CMV IgM antibodies was 8.2% (49/600) (95% CI 6% to 10.5%), whereas the CMV IgG was 88.7% (532/600), (95% CI 89.5% to 94.0%). Seroprevalence of CMV IgM was higher in women of older age, currently unmarried, having nursery schooled children and with any of the detected curable sexually transmitted infections, while seroprevalence of CMV IgG was significantly associated only with women having nursery schooled children. Seroprevalence was not significantly associated with previous adverse pregnancy outcome, gravidity, being a child daycare occupant mother and newborn birth weight. CONCLUSION: In the present study, we identified a high rate of CMV IgM and CMV IgG seroprevalence among pregnant women in Southern Ethiopia. Given that there is no existing CMV diagnosis, special attention should be designed to pregnant women in parallel to the existing antenatal care facility. Besides, training healthcare professionals will support awareness conception among pregnant women concerning the sequels of CMV infection during pregnancy. BMJ Publishing Group 2021-10-21 /pmc/articles/PMC8532544/ /pubmed/34675017 http://dx.doi.org/10.1136/bmjopen-2021-051390 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Obstetrics and Gynaecology
Zenebe, Mengistu Hailemariam
Mekonnen, Zeleke
Loha, Eskindir
Padalko, Elizaveta
Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study
title Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study
title_full Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study
title_fullStr Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study
title_full_unstemmed Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study
title_short Seroprevalence and associated factors of maternal cytomegalovirus in Southern Ethiopia: a cross-sectional study
title_sort seroprevalence and associated factors of maternal cytomegalovirus in southern ethiopia: a cross-sectional study
topic Obstetrics and Gynaecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532544/
https://www.ncbi.nlm.nih.gov/pubmed/34675017
http://dx.doi.org/10.1136/bmjopen-2021-051390
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