Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide

The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3–12) were isolated. Previously reported compounds we...

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Detalles Bibliográficos
Autores principales: Elshamy, Abdelsamed I., Mohamed, Tarik A., Elkady, Eman M., Saleh, Ibrahim A., El-Beih, Ahmed A., Alhammady, Montaser A., Ohta, Shinji, Umeyama, Akemi, Paré, Paul W., Hegazy, Mohamed-Elamir F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532672/
https://www.ncbi.nlm.nih.gov/pubmed/34680740
http://dx.doi.org/10.3390/antibiotics10101158
Descripción
Sumario:The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3–12) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (1–12) against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. Compound 5 showed antimicrobial activity against all assayed microorganisms.

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