Cargando…
Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532852/ https://www.ncbi.nlm.nih.gov/pubmed/34680725 http://dx.doi.org/10.3390/antibiotics10101144 |
_version_ | 1784587169002684416 |
---|---|
author | Sokolewicz, Ewa Maria Rogowska, Martyna Lewandowski, Miłosz Puchowska, Monika Piechota, Dorota Barańska-Rybak, Wioletta |
author_facet | Sokolewicz, Ewa Maria Rogowska, Martyna Lewandowski, Miłosz Puchowska, Monika Piechota, Dorota Barańska-Rybak, Wioletta |
author_sort | Sokolewicz, Ewa Maria |
collection | PubMed |
description | Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the department of Dermatology, Venerology and Allergology of the University Clinical Center in Gdańsk, Poland, in the years 2004–2021. A retrospective analysis of patients’ medical files was conducted in order to identify cases of ADR connected with the use of antibiotics, yielding 84 cases. The most common group of antibiotics were β-lactam, causing ADR in 47 patients. β-lactam antibiotics in our study included amoxicillin, alone and combined with clavulanic acid, and cephalosporins, affecting 22, 18 and 7 patients, respectively. In conclusion, β-lactam antibiotics showed the highest prevalence among antibiotic-induced skin reactions. They accounted for 15% of cases of all dermatological drug reactions and 55% of those caused by antibiotics. Especially amoxicillin, prescribed as a single drug or in combination with clavulanic acid, was commonly the culprit. Due to its wide use in the hospital and outpatient clinic, these adverse reactions have to be kept in mind by both hospital staff and general practitioners. |
format | Online Article Text |
id | pubmed-8532852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85328522021-10-23 Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk Sokolewicz, Ewa Maria Rogowska, Martyna Lewandowski, Miłosz Puchowska, Monika Piechota, Dorota Barańska-Rybak, Wioletta Antibiotics (Basel) Article Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the department of Dermatology, Venerology and Allergology of the University Clinical Center in Gdańsk, Poland, in the years 2004–2021. A retrospective analysis of patients’ medical files was conducted in order to identify cases of ADR connected with the use of antibiotics, yielding 84 cases. The most common group of antibiotics were β-lactam, causing ADR in 47 patients. β-lactam antibiotics in our study included amoxicillin, alone and combined with clavulanic acid, and cephalosporins, affecting 22, 18 and 7 patients, respectively. In conclusion, β-lactam antibiotics showed the highest prevalence among antibiotic-induced skin reactions. They accounted for 15% of cases of all dermatological drug reactions and 55% of those caused by antibiotics. Especially amoxicillin, prescribed as a single drug or in combination with clavulanic acid, was commonly the culprit. Due to its wide use in the hospital and outpatient clinic, these adverse reactions have to be kept in mind by both hospital staff and general practitioners. MDPI 2021-09-22 /pmc/articles/PMC8532852/ /pubmed/34680725 http://dx.doi.org/10.3390/antibiotics10101144 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sokolewicz, Ewa Maria Rogowska, Martyna Lewandowski, Miłosz Puchowska, Monika Piechota, Dorota Barańska-Rybak, Wioletta Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk |
title | Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk |
title_full | Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk |
title_fullStr | Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk |
title_full_unstemmed | Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk |
title_short | Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk |
title_sort | antibiotic-related adverse drug reactions in patients treated on the dermatology ward of medical university of gdańsk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532852/ https://www.ncbi.nlm.nih.gov/pubmed/34680725 http://dx.doi.org/10.3390/antibiotics10101144 |
work_keys_str_mv | AT sokolewiczewamaria antibioticrelatedadversedrugreactionsinpatientstreatedonthedermatologywardofmedicaluniversityofgdansk AT rogowskamartyna antibioticrelatedadversedrugreactionsinpatientstreatedonthedermatologywardofmedicaluniversityofgdansk AT lewandowskimiłosz antibioticrelatedadversedrugreactionsinpatientstreatedonthedermatologywardofmedicaluniversityofgdansk AT puchowskamonika antibioticrelatedadversedrugreactionsinpatientstreatedonthedermatologywardofmedicaluniversityofgdansk AT piechotadorota antibioticrelatedadversedrugreactionsinpatientstreatedonthedermatologywardofmedicaluniversityofgdansk AT baranskarybakwioletta antibioticrelatedadversedrugreactionsinpatientstreatedonthedermatologywardofmedicaluniversityofgdansk |