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Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk

Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the...

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Autores principales: Sokolewicz, Ewa Maria, Rogowska, Martyna, Lewandowski, Miłosz, Puchowska, Monika, Piechota, Dorota, Barańska-Rybak, Wioletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532852/
https://www.ncbi.nlm.nih.gov/pubmed/34680725
http://dx.doi.org/10.3390/antibiotics10101144
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author Sokolewicz, Ewa Maria
Rogowska, Martyna
Lewandowski, Miłosz
Puchowska, Monika
Piechota, Dorota
Barańska-Rybak, Wioletta
author_facet Sokolewicz, Ewa Maria
Rogowska, Martyna
Lewandowski, Miłosz
Puchowska, Monika
Piechota, Dorota
Barańska-Rybak, Wioletta
author_sort Sokolewicz, Ewa Maria
collection PubMed
description Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the department of Dermatology, Venerology and Allergology of the University Clinical Center in Gdańsk, Poland, in the years 2004–2021. A retrospective analysis of patients’ medical files was conducted in order to identify cases of ADR connected with the use of antibiotics, yielding 84 cases. The most common group of antibiotics were β-lactam, causing ADR in 47 patients. β-lactam antibiotics in our study included amoxicillin, alone and combined with clavulanic acid, and cephalosporins, affecting 22, 18 and 7 patients, respectively. In conclusion, β-lactam antibiotics showed the highest prevalence among antibiotic-induced skin reactions. They accounted for 15% of cases of all dermatological drug reactions and 55% of those caused by antibiotics. Especially amoxicillin, prescribed as a single drug or in combination with clavulanic acid, was commonly the culprit. Due to its wide use in the hospital and outpatient clinic, these adverse reactions have to be kept in mind by both hospital staff and general practitioners.
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spelling pubmed-85328522021-10-23 Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk Sokolewicz, Ewa Maria Rogowska, Martyna Lewandowski, Miłosz Puchowska, Monika Piechota, Dorota Barańska-Rybak, Wioletta Antibiotics (Basel) Article Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the department of Dermatology, Venerology and Allergology of the University Clinical Center in Gdańsk, Poland, in the years 2004–2021. A retrospective analysis of patients’ medical files was conducted in order to identify cases of ADR connected with the use of antibiotics, yielding 84 cases. The most common group of antibiotics were β-lactam, causing ADR in 47 patients. β-lactam antibiotics in our study included amoxicillin, alone and combined with clavulanic acid, and cephalosporins, affecting 22, 18 and 7 patients, respectively. In conclusion, β-lactam antibiotics showed the highest prevalence among antibiotic-induced skin reactions. They accounted for 15% of cases of all dermatological drug reactions and 55% of those caused by antibiotics. Especially amoxicillin, prescribed as a single drug or in combination with clavulanic acid, was commonly the culprit. Due to its wide use in the hospital and outpatient clinic, these adverse reactions have to be kept in mind by both hospital staff and general practitioners. MDPI 2021-09-22 /pmc/articles/PMC8532852/ /pubmed/34680725 http://dx.doi.org/10.3390/antibiotics10101144 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sokolewicz, Ewa Maria
Rogowska, Martyna
Lewandowski, Miłosz
Puchowska, Monika
Piechota, Dorota
Barańska-Rybak, Wioletta
Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
title Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
title_full Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
title_fullStr Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
title_full_unstemmed Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
title_short Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk
title_sort antibiotic-related adverse drug reactions in patients treated on the dermatology ward of medical university of gdańsk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532852/
https://www.ncbi.nlm.nih.gov/pubmed/34680725
http://dx.doi.org/10.3390/antibiotics10101144
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