Cargando…

Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy

This study is a retrospective epidemiological assessment of bacterial species isolated from a cohort of out-patients with diabetic foot infections referred to our “Diabetic Foot Unit” over one year, with particular attention to index pathogens, as identified by the EARS Network. Staphylococcus aureu...

Descripción completa

Detalles Bibliográficos
Autores principales: Boschetti, Giovanni, Sgarabotto, Dino, Meloni, Marco, Bruseghin, Marino, Whisstock, Christine, Marin, Mariagrazia, Ninkovic, Sasa, Pinfi, Michela, Brocco, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532857/
https://www.ncbi.nlm.nih.gov/pubmed/34680820
http://dx.doi.org/10.3390/antibiotics10101241
_version_ 1784587170201206784
author Boschetti, Giovanni
Sgarabotto, Dino
Meloni, Marco
Bruseghin, Marino
Whisstock, Christine
Marin, Mariagrazia
Ninkovic, Sasa
Pinfi, Michela
Brocco, Enrico
author_facet Boschetti, Giovanni
Sgarabotto, Dino
Meloni, Marco
Bruseghin, Marino
Whisstock, Christine
Marin, Mariagrazia
Ninkovic, Sasa
Pinfi, Michela
Brocco, Enrico
author_sort Boschetti, Giovanni
collection PubMed
description This study is a retrospective epidemiological assessment of bacterial species isolated from a cohort of out-patients with diabetic foot infections referred to our “Diabetic Foot Unit” over one year, with particular attention to index pathogens, as identified by the EARS Network. Staphylococcus aureus and Pseudomonas aeruginosa accounted for 33.5% and 11.9% of cases, respectively. MRSA was isolated in 27.1% of patients, with 14.06% showing additional resistance to three antimicrobial classes. Pseudomonas aeruginosa presented extensive resistance to fluoroquinolones (57.3%), which was associated with resistance to piperacillin in 17.6% or to carbapenems in 23.5% of cases. Other pathogens, such as methicillin resistant Staphylococcus epidermidis, Escherichia coli and Morganella morganii ESBL and Enterococcus faecium VRE, were also found.
format Online
Article
Text
id pubmed-8532857
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85328572021-10-23 Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy Boschetti, Giovanni Sgarabotto, Dino Meloni, Marco Bruseghin, Marino Whisstock, Christine Marin, Mariagrazia Ninkovic, Sasa Pinfi, Michela Brocco, Enrico Antibiotics (Basel) Article This study is a retrospective epidemiological assessment of bacterial species isolated from a cohort of out-patients with diabetic foot infections referred to our “Diabetic Foot Unit” over one year, with particular attention to index pathogens, as identified by the EARS Network. Staphylococcus aureus and Pseudomonas aeruginosa accounted for 33.5% and 11.9% of cases, respectively. MRSA was isolated in 27.1% of patients, with 14.06% showing additional resistance to three antimicrobial classes. Pseudomonas aeruginosa presented extensive resistance to fluoroquinolones (57.3%), which was associated with resistance to piperacillin in 17.6% or to carbapenems in 23.5% of cases. Other pathogens, such as methicillin resistant Staphylococcus epidermidis, Escherichia coli and Morganella morganii ESBL and Enterococcus faecium VRE, were also found. MDPI 2021-10-13 /pmc/articles/PMC8532857/ /pubmed/34680820 http://dx.doi.org/10.3390/antibiotics10101241 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boschetti, Giovanni
Sgarabotto, Dino
Meloni, Marco
Bruseghin, Marino
Whisstock, Christine
Marin, Mariagrazia
Ninkovic, Sasa
Pinfi, Michela
Brocco, Enrico
Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy
title Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy
title_full Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy
title_fullStr Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy
title_full_unstemmed Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy
title_short Antimicrobial Resistance Patterns in Diabetic Foot Infections, an Epidemiological Study in Northeastern Italy
title_sort antimicrobial resistance patterns in diabetic foot infections, an epidemiological study in northeastern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532857/
https://www.ncbi.nlm.nih.gov/pubmed/34680820
http://dx.doi.org/10.3390/antibiotics10101241
work_keys_str_mv AT boschettigiovanni antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT sgarabottodino antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT melonimarco antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT bruseghinmarino antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT whisstockchristine antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT marinmariagrazia antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT ninkovicsasa antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT pinfimichela antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly
AT broccoenrico antimicrobialresistancepatternsindiabeticfootinfectionsanepidemiologicalstudyinnortheasternitaly