Seroprevalence and Molecular Epidemiology of Aleutian Disease in Various Countries during 1972–2021: A Review and Meta-Analysis

SIMPLE SUMMARY: Aleutian disease is caused by the Aleutian mink disease virus and is one of the most serious infectious diseases that affect the family Mustelidae, including the American mink, wild European mink, weasels, badgers and other animal species, such as skunks, raccoons, dogs, cats and mice, as well as humans. Effective treatments and vaccines against Aleutian disease have not been developed to date. Prophylactic programs that focus on the identification and elimination of infected mink are one of the methods of controlling the negative outcomes of Aleutian disease. This article analyses the seroprevalence of Aleutian mink disease virus infections in American and European mink and other species around the world, and reviews recent knowledge relating to the molecular epidemiology of the Aleutian mink disease virus. ABSTRACT: Aleutian disease (AD) poses a serious threat to both free-ranging and farmed mink around the world. The disease is caused by the Aleutian mink disease virus (AMDV), which also poses a health risk for other members of the family Mustelidae, including wild mink, weasels, badgers and other animal species. This article analyses the seroprevalence of AMDV infections in mink and other species around the world, and reviews recent knowledge relating to the molecular epidemiology of the AMDV. Depending on the applied diagnostic technique and the country, the prevalence of anti-AMDV antibodies or AMDV DNA was established at 21.60–100.00% in farmed American mink, 0.00–93.30% in free-ranging American mink and 0.00–25.00% in European mink. Anti-AMDV antibodies or AMDV DNA were also detected in other free-living fur-bearing animals in Europe and Canada, where their prevalence was determined at 0.00–32.00% and 0.00–70.50%, respectively. This may indicate a potential threat to various animal species. AMDV strains are not clustered into genotypes based on the geographic origin, year of isolation or pathogenicity. The isolates that were identified on mink farms around the world originated from North America because American mink were introduced to Europe and Asia for breeding purposes and to restock natural populations.