Cargando…

An Enzybiotic Regimen for the Treatment of Methicillin-Resistant Staphylococcus aureus Orthopaedic Device-Related Infection

Orthopaedic device-related infection (ODRI) presents a significant challenge to the field of orthopaedic and trauma surgery. Despite extensive treatment involving surgical debridement and prolonged antibiotic therapy, outcomes remain poor. This is largely due to the unique abilities of Staphylococcu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sumrall, Eric T., Hofstee, Marloes I., Arens, Daniel, Röhrig, Christian, Baertl, Susanne, Gehweiler, Dominic, Schmelcher, Mathias, Loessner, Martin J., Zeiter, Stephan, Richards, R. Geoff, Moriarty, T. Fintan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533017/ https://www.ncbi.nlm.nih.gov/pubmed/34680767 http://dx.doi.org/10.3390/antibiotics10101186

Ejemplares similares

Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus
por: Röhrig, Christian, et al.
Publicado: (2020)

An Engineered Multimodular Enzybiotic against Methicillin-Resistant Staphylococcus aureus
por: Manoharadas, Salim, et al.
Publicado: (2021)

Resensitisation of Methicillin-Resistant Staphylococcus aureus to Conventional Antibiotics in the Presence of an Engineered Enzybiotic
por: Manoharadas, Salim, et al.
Publicado: (2023)

Comparative bone healing with induced membrane technique (IMT) versus empty defects in septic and aseptic conditions in a novel rabbit humerus model
por: Siverino, Claudia, et al.
Publicado: (2023)

Glycotyping and Specific Separation of Listeria monocytogenes with a Novel Bacteriophage Protein Tool Kit
por: Sumrall, Eric T., et al.
Publicado: (2020)

In Vitro 3D Staphylococcus aureus Abscess Communities Induce Bone Marrow Cells to Expand into Myeloid-Derived Suppressor Cells
por: Hofstee, Marloes I., et al.
Publicado: (2021)

An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection
por: Boot, Willemijn, et al.
Publicado: (2022)

Continuous Implant Load Monitoring to Assess Bone Healing Status—Evidence from Animal Testing
por: Windolf, Markus, et al.
Publicado: (2022)

Intraoperative loading of calcium phosphate-coated implants with gentamicin prevents experimental Staphylococcus aureus infection in vivo
por: Thompson, Keith, et al.
Publicado: (2019)

LYZ2-SH3b as a novel and efficient enzybiotic against methicillin-resistant Staphylococcus aureus
por: Asadi, Marzieh, et al.
Publicado: (2023)

Phages and Enzybiotics in Food Biopreservation
por: Ramos-Vivas, José, et al.
Publicado: (2021)

Fracture-related infection
por: Baertl, Susanne, et al.
Publicado: (2021)

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis
por: Muthukrishnan, Gowrishankar, et al.
Publicado: (2021)

Enzybiotic-mediated antimicrobial functionalization of polyhydroxyalkanoates
por: Blanco, Francisco G., et al.
Publicado: (2023)

LytU-SH3b fusion protein as a novel and efficient enzybiotic against methicillin-resistant Staphylococcus aureus
por: Taheri-Anganeh, Mortaza, et al.
Publicado: (2019)

Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice
por: Wallimann, Alexandra, et al.
Publicado: (2021)

Local Bacteriophage Delivery for Treatment and Prevention of Bacterial Infections
por: Rotman, Stijn Gerard, et al.
Publicado: (2020)

GMEnzy: A Genetically Modified Enzybiotic Database
por: Wu, Hongyu, et al.
Publicado: (2014)

Domain shuffling and module engineering of Listeria phage endolysins for enhanced lytic activity and binding affinity
por: Schmelcher, Mathias, et al.
Publicado: (2011)

EnzyBase: a novel database for enzybiotic studies
por: Wu, Hongyu, et al.
Publicado: (2012)

Ultrasensitive and Fast Diagnostics of Viable Listeria Cells by CBD Magnetic Separation Combined with A511::luxAB Detection
por: Kretzer, Jan W., et al.
Publicado: (2018)

An Enzybiotic Cocktail Effectively Disrupts Preformed Dual Biofilm of Staphylococcus aureus and Enterococcus faecalis
por: Manoharadas, Salim, et al.
Publicado: (2023)

Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model
por: Sabaté-Brescó, Marina, et al.
Publicado: (2021)

Titanium Wear Particles Exacerbate S. epidermidis-Induced Implant-Related Osteolysis and Decrease Efficacy of Antibiotic Therapy
por: Siverino, Claudia, et al.
Publicado: (2021)

Orthopaedic device-related infection: current and future interventions for improved prevention and treatment
por: Moriarty, T. Fintan, et al.
Publicado: (2016)

Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic Staphylococcus aureus Infection
por: Sobieraj, Anna M., et al.
Publicado: (2020)

Longitudinal time-lapse in vivo micro-CT reveals differential patterns of peri-implant bone changes after subclinical bacterial infection in a rat model
por: Stadelmann, Vincent A., et al.
Publicado: (2020)

Development and Characterization of a Subcutaneous Implant-Related Infection Model in Mice to Test Novel Antimicrobial Treatment Strategies
por: Wittmann, Charlotte, et al.
Publicado: (2022)

Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletion
por: Zinsli, Léa V., et al.
Publicado: (2020)

Staphylococcus aureus Specific Electrospun Wound Dressings: Influence of Immobilization Technique on Antibacterial Efficiency of Novel Enzybiotic
por: Urbanek, Olga, et al.
Publicado: (2021)

phiBIOTICS: catalogue of therapeutic enzybiotics, relevant research studies and practical applications
por: Hojckova, Katarina, et al.
Publicado: (2013)

Enzybiotics LYSSTAPH-S and LYSDERM-S as Potential Therapeutic Agents for Chronic MRSA Wound Infections
por: Vacek, Lukáš, et al.
Publicado: (2020)

Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application
por: Danis-Wlodarczyk, Katarzyna M., et al.
Publicado: (2021)

Inflammatory Response of Primary Cultured Bovine Mammary Epithelial Cells to Staphylococcus aureus Extracellular Vesicles
por: Saenz-de-Juano, Mara D., et al.
Publicado: (2022)

Is a Block of the Femoral and Sciatic Nerves an Alternative to Epidural Analgesia in Sheep Undergoing Orthopaedic Hind Limb Surgery? A Prospective, Randomized, Double Blinded Experimental Trial
por: Stenger, Valentina, et al.
Publicado: (2021)

Mining of Gram-Negative Surface-Active Enzybiotic Candidates by Sequence-Based Calculation of Physicochemical Properties
por: Vázquez, Roberto, et al.
Publicado: (2021)

Structural and functional features of a broad-spectrum prophage-encoded enzybiotic from Enterococcus faecium
por: Premetis, Georgios E., et al.
Publicado: (2023)

Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells
por: Keller, Anja P., et al.
Publicado: (2022)

Humoral Factors From Musculoskeletal Polytrauma Patients Impair Antibacterial Responses Of Neutrophils In vitro
por: Stylianaki, Aikaterini, et al.
Publicado: (2019)

Does Metaphyseal Cement Augmentation in Fracture Management Influence the Adjacent Subchondral Bone and Joint Cartilage?: An In Vivo Study in Sheep Stifle Joints
por: Goetzen, Michael, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_65isch0auk1fobbae5l04kms9c