Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma

Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Pérez-Ruiz, Elisabeth, Gutiérrez, Vanesa, Muñoz, Marta, Oliver, Javier, Sánchez, Marta, Gálvez-Carvajal, Laura, Rueda-Domínguez, Antonio, Barragán, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533108/
https://www.ncbi.nlm.nih.gov/pubmed/34680596
http://dx.doi.org/10.3390/biomedicines9101478
_version_ 1784587232224477184
author Pérez-Ruiz, Elisabeth
Gutiérrez, Vanesa
Muñoz, Marta
Oliver, Javier
Sánchez, Marta
Gálvez-Carvajal, Laura
Rueda-Domínguez, Antonio
Barragán, Isabel
author_facet Pérez-Ruiz, Elisabeth
Gutiérrez, Vanesa
Muñoz, Marta
Oliver, Javier
Sánchez, Marta
Gálvez-Carvajal, Laura
Rueda-Domínguez, Antonio
Barragán, Isabel
author_sort Pérez-Ruiz, Elisabeth
collection PubMed
description Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.
format Online
Article
Text
id pubmed-8533108
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85331082021-10-23 Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma Pérez-Ruiz, Elisabeth Gutiérrez, Vanesa Muñoz, Marta Oliver, Javier Sánchez, Marta Gálvez-Carvajal, Laura Rueda-Domínguez, Antonio Barragán, Isabel Biomedicines Review Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours. MDPI 2021-10-15 /pmc/articles/PMC8533108/ /pubmed/34680596 http://dx.doi.org/10.3390/biomedicines9101478 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pérez-Ruiz, Elisabeth
Gutiérrez, Vanesa
Muñoz, Marta
Oliver, Javier
Sánchez, Marta
Gálvez-Carvajal, Laura
Rueda-Domínguez, Antonio
Barragán, Isabel
Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
title Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
title_full Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
title_fullStr Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
title_full_unstemmed Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
title_short Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
title_sort liquid biopsy as a tool for the characterisation and early detection of the field cancerization effect in patients with oral cavity carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533108/
https://www.ncbi.nlm.nih.gov/pubmed/34680596
http://dx.doi.org/10.3390/biomedicines9101478
work_keys_str_mv AT perezruizelisabeth liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT gutierrezvanesa liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT munozmarta liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT oliverjavier liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT sanchezmarta liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT galvezcarvajallaura liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT ruedadominguezantonio liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma
AT barraganisabel liquidbiopsyasatoolforthecharacterisationandearlydetectionofthefieldcancerizationeffectinpatientswithoralcavitycarcinoma

Ejemplares similares