Changes in MOTS-c Level in the Blood of Pregnant Women with Metabolic Disorders

SIMPLE SUMMARY: Metabolic relationships between mother and child are currently some of the most studied in the context of maternal imprinting. This is particularly important in the context of metabolic diseases as well as newly discovered peptides, proteins, and biologically active substances produced in the bodies of a mother and child. One of them is MOTS-c, which belongs to the group of mitochondria-derived peptides (MDP). The first reports show that it plays an important metabolic role in carbohydrate–lipid metabolism. We decided to investigate the concentration changes in MOTS-c levels in maternal and umbilical cord blood at delivery in healthy, obese, and hypothyroidism subjects. We found changes in MOTS-c levels depending on the metabolic condition of mothers. ABSTRACT: MOTS-c peptide is a member of the group of mitochondria-derived peptides (MDP). It is a product of the open reading frame in the 12S RNA gene. Due to its features and functions in the body, this peptide is classified as a hormone. The first publications indicated that this hormone improves insulin sensitivity and lowers body weight in obese animals. This suggests that it may be an important peptide in maintaining the body’s energy homeostasis. The aim of our work was to investigate the potential role of MOTS-c peptide during pregnancy, which is a condition prone to metabolic disorders. The research covered healthy, obese women and women with thyroid disorders. The obtained results indicated an increase in the concentration of MOTS-c in the blood of mothers and newborns in the obese group as compared to the healthy control group and a corresponding decrease in the concentration of this peptide in mothers and newborns in the group with hypothyroidism compared to the obese group. Moreover, we also observed a strong positive correlation between the concentration of MOTS-c in maternal blood and in umbilical cord blood. In summary, the MOTS-c peptide shows changes in blood concentration in various physiological states and may, in the future, become an important tool in the fight against metabolic diseases such as obesity or type 2 diabetes.