Cargando…
Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R)
Chronic hepatitis C can be treated very effectively with direct-acting antivirals (DAA) with only minor side effects compared to an interferon-containing treatment regimen. The significance of metabolic comorbidities after HCV cure is not well defined. This study aims to investigate short- and long-...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533115/ https://www.ncbi.nlm.nih.gov/pubmed/34680612 http://dx.doi.org/10.3390/biomedicines9101495 |
_version_ | 1784587233913733120 |
---|---|
author | Schlevogt, Bernhard Boeker, Klaus H. W. Mauss, Stefan Klinker, Hartwig Heyne, Renate Link, Ralph Simon, Karl-Georg Sarrazin, Christoph Serfert, Yvonne Manns, Michael P. Wedemeyer, Heiner |
author_facet | Schlevogt, Bernhard Boeker, Klaus H. W. Mauss, Stefan Klinker, Hartwig Heyne, Renate Link, Ralph Simon, Karl-Georg Sarrazin, Christoph Serfert, Yvonne Manns, Michael P. Wedemeyer, Heiner |
author_sort | Schlevogt, Bernhard |
collection | PubMed |
description | Chronic hepatitis C can be treated very effectively with direct-acting antivirals (DAA) with only minor side effects compared to an interferon-containing treatment regimen. The significance of metabolic comorbidities after HCV cure is not well defined. This study aims to investigate short- and long-term weight change of patients receiving interferon-free antiviral treatment for chronic hepatitis C. The German Hepatitis C-registry (DHC-R) is a national multicenter real-world cohort. A total of 5111 patients were followed prospectively after DAA treatment for up to 3 years. Weight change compared to baseline was analyzed at end of treatment and at years 1, 2, and 3 after completion of antiviral therapy. Regression analysis was performed to identify baseline predictors for weight change. While there was no relevant mean weight change (−0.2 kg, SD 4.3 kg) at the end of antiviral treatment, weight started to increase during long-term follow-up reaching +1.7 kg (SD 8.0 kg, p < 0.001) compared to baseline at 3 years (follow-up year 3, FU3) after completion of antiviral therapy. 48%, 31%, and 22% of patients had a weight gain greater than 1, 3, and 5 kg at FU3, respectively. During follow-up, a body mass index (BMI) <30 proved to be the only consistent predictor for weight gain. DAA treatment is followed by a substantial weight gain (+3 kg or more) in one-third of the patients during long-term follow-up. Non-obese patients seemed to be most vulnerable to weight gain. The body compartment involved in weight gain as well as the mechanism of weight gain remain to be elucidated. |
format | Online Article Text |
id | pubmed-8533115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85331152021-10-23 Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) Schlevogt, Bernhard Boeker, Klaus H. W. Mauss, Stefan Klinker, Hartwig Heyne, Renate Link, Ralph Simon, Karl-Georg Sarrazin, Christoph Serfert, Yvonne Manns, Michael P. Wedemeyer, Heiner Biomedicines Article Chronic hepatitis C can be treated very effectively with direct-acting antivirals (DAA) with only minor side effects compared to an interferon-containing treatment regimen. The significance of metabolic comorbidities after HCV cure is not well defined. This study aims to investigate short- and long-term weight change of patients receiving interferon-free antiviral treatment for chronic hepatitis C. The German Hepatitis C-registry (DHC-R) is a national multicenter real-world cohort. A total of 5111 patients were followed prospectively after DAA treatment for up to 3 years. Weight change compared to baseline was analyzed at end of treatment and at years 1, 2, and 3 after completion of antiviral therapy. Regression analysis was performed to identify baseline predictors for weight change. While there was no relevant mean weight change (−0.2 kg, SD 4.3 kg) at the end of antiviral treatment, weight started to increase during long-term follow-up reaching +1.7 kg (SD 8.0 kg, p < 0.001) compared to baseline at 3 years (follow-up year 3, FU3) after completion of antiviral therapy. 48%, 31%, and 22% of patients had a weight gain greater than 1, 3, and 5 kg at FU3, respectively. During follow-up, a body mass index (BMI) <30 proved to be the only consistent predictor for weight gain. DAA treatment is followed by a substantial weight gain (+3 kg or more) in one-third of the patients during long-term follow-up. Non-obese patients seemed to be most vulnerable to weight gain. The body compartment involved in weight gain as well as the mechanism of weight gain remain to be elucidated. MDPI 2021-10-19 /pmc/articles/PMC8533115/ /pubmed/34680612 http://dx.doi.org/10.3390/biomedicines9101495 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schlevogt, Bernhard Boeker, Klaus H. W. Mauss, Stefan Klinker, Hartwig Heyne, Renate Link, Ralph Simon, Karl-Georg Sarrazin, Christoph Serfert, Yvonne Manns, Michael P. Wedemeyer, Heiner Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) |
title | Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) |
title_full | Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) |
title_fullStr | Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) |
title_full_unstemmed | Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) |
title_short | Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R) |
title_sort | weight gain after interferon-free treatment of chronic hepatitis c—results from the german hepatitis c-registry (dhc-r) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533115/ https://www.ncbi.nlm.nih.gov/pubmed/34680612 http://dx.doi.org/10.3390/biomedicines9101495 |
work_keys_str_mv | AT schlevogtbernhard weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT boekerklaushw weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT maussstefan weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT klinkerhartwig weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT heynerenate weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT linkralph weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT simonkarlgeorg weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT sarrazinchristoph weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT serfertyvonne weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT mannsmichaelp weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr AT wedemeyerheiner weightgainafterinterferonfreetreatmentofchronichepatitiscresultsfromthegermanhepatitiscregistrydhcr |