Cargando…

Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection

SARS-CoV-2 infection has been related to adverse pregnancy outcomes. A placental role in protecting the fetus from SARS-CoV-2 infection has been documented. Nevertheless, it is still unclear how the placenta is affected in SARS-CoV-2 infection. Here we assessed placental mitochondrial (mt) and oxida...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandò, Chiara, Savasi, Valeria M., Anelli, Gaia M., Corti, Silvia, Serati, Anaïs, Lisso, Fabrizia, Tasca, Chiara, Novielli, Chiara, Cetin, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533135/
https://www.ncbi.nlm.nih.gov/pubmed/34679654
http://dx.doi.org/10.3390/antiox10101517
_version_ 1784587238706774016
author Mandò, Chiara
Savasi, Valeria M.
Anelli, Gaia M.
Corti, Silvia
Serati, Anaïs
Lisso, Fabrizia
Tasca, Chiara
Novielli, Chiara
Cetin, Irene
author_facet Mandò, Chiara
Savasi, Valeria M.
Anelli, Gaia M.
Corti, Silvia
Serati, Anaïs
Lisso, Fabrizia
Tasca, Chiara
Novielli, Chiara
Cetin, Irene
author_sort Mandò, Chiara
collection PubMed
description SARS-CoV-2 infection has been related to adverse pregnancy outcomes. A placental role in protecting the fetus from SARS-CoV-2 infection has been documented. Nevertheless, it is still unclear how the placenta is affected in SARS-CoV-2 infection. Here we assessed placental mitochondrial (mt) and oxidative features in COVID-19 and healthy mothers. mtDNA levels, DNA oxidative damage, expression levels of genes involved in antioxidant defenses, mitochondrial dynamics and respiratory chain subunits were investigated in placentas from singleton pregnancies of 30 women with SARS-CoV-2 infection during the third trimester (12 asymptomatic, 18 symptomatic) and 16 controls. mtDNA levels decreased in COVID-19 placentas vs. controls and inversely correlated with DNA oxidative damage, which increased in the symptomatic group. Antioxidant gene expressions decreased in SARS-CoV-2 mothers (CAT, GSS). Symptomatic cases also showed a lower expression of respiratory chain (NDUFA9, SDHA, COX4I1) and mt dynamics (DNM1L, FIS1) genes. Alterations in placental mitochondrial features and oxidative balance in COVID-19-affected mothers might be due to the impaired intrauterine environment, generated by systemic viral effects, leading to a negative vicious circle that worsens placental oxidative stress and mitochondrial efficiency. This likely causes cell homeostasis dysregulations, raising the potential of possible long-term effects.
format Online
Article
Text
id pubmed-8533135
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85331352021-10-23 Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection Mandò, Chiara Savasi, Valeria M. Anelli, Gaia M. Corti, Silvia Serati, Anaïs Lisso, Fabrizia Tasca, Chiara Novielli, Chiara Cetin, Irene Antioxidants (Basel) Article SARS-CoV-2 infection has been related to adverse pregnancy outcomes. A placental role in protecting the fetus from SARS-CoV-2 infection has been documented. Nevertheless, it is still unclear how the placenta is affected in SARS-CoV-2 infection. Here we assessed placental mitochondrial (mt) and oxidative features in COVID-19 and healthy mothers. mtDNA levels, DNA oxidative damage, expression levels of genes involved in antioxidant defenses, mitochondrial dynamics and respiratory chain subunits were investigated in placentas from singleton pregnancies of 30 women with SARS-CoV-2 infection during the third trimester (12 asymptomatic, 18 symptomatic) and 16 controls. mtDNA levels decreased in COVID-19 placentas vs. controls and inversely correlated with DNA oxidative damage, which increased in the symptomatic group. Antioxidant gene expressions decreased in SARS-CoV-2 mothers (CAT, GSS). Symptomatic cases also showed a lower expression of respiratory chain (NDUFA9, SDHA, COX4I1) and mt dynamics (DNM1L, FIS1) genes. Alterations in placental mitochondrial features and oxidative balance in COVID-19-affected mothers might be due to the impaired intrauterine environment, generated by systemic viral effects, leading to a negative vicious circle that worsens placental oxidative stress and mitochondrial efficiency. This likely causes cell homeostasis dysregulations, raising the potential of possible long-term effects. MDPI 2021-09-24 /pmc/articles/PMC8533135/ /pubmed/34679654 http://dx.doi.org/10.3390/antiox10101517 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mandò, Chiara
Savasi, Valeria M.
Anelli, Gaia M.
Corti, Silvia
Serati, Anaïs
Lisso, Fabrizia
Tasca, Chiara
Novielli, Chiara
Cetin, Irene
Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection
title Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection
title_full Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection
title_fullStr Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection
title_full_unstemmed Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection
title_short Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection
title_sort mitochondrial and oxidative unbalance in placentas from mothers with sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533135/
https://www.ncbi.nlm.nih.gov/pubmed/34679654
http://dx.doi.org/10.3390/antiox10101517
work_keys_str_mv AT mandochiara mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT savasivaleriam mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT anelligaiam mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT cortisilvia mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT seratianais mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT lissofabrizia mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT tascachiara mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT noviellichiara mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection
AT cetinirene mitochondrialandoxidativeunbalanceinplacentasfrommotherswithsarscov2infection